Al Mouslmani, Mohammad, Sawano, Mitsuaki, Arun, Adith S et al. · JACC. Advances · 2025 · DOI
This study looked at people with long COVID who also developed POTS (a condition where the heart rate spikes when standing up). Among nearly 600 long COVID patients, about 29% reported having POTS. People with both conditions reported significantly more symptoms—including dizziness, chest pain, extreme fatigue, difficulty exercising, and brain fog—and experienced worse overall health and quality of life compared to those with long COVID alone.
POTS appears frequently in long COVID and ME/CFS populations and is associated with substantial clinical burden. Understanding the prevalence, symptom clustering, and disease severity in long COVID-associated POTS helps validate patient experiences, informs clinical recognition, and underscores the need for mechanistic research and targeted interventions for this underrecognized phenotype.
This study does not establish whether POTS causes the observed symptoms, whether COVID directly triggered POTS development, or whether the findings generalize beyond online-survey participants. Self-reported diagnosis is not confirmed by objective testing (tilt-table testing, continuous heart rate monitoring), so actual POTS prevalence may differ from the reported 28.9%. Cross-sectional data cannot prove temporal relationships or mechanism.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Al Mouslmani, Mohammad, Sawano, Mitsuaki, Arun, Adith S, Wu, Yilun, Shah, Rishi M, Kaleem, Shayaan, et al. (2025). Characterization of Postural Orthostatic Tachycardia Syndrome in Long COVID: Self-reported Data From the LISTEN Study.. JACC. Advances. https://doi.org/10.1016/j.jacadv.2025.101873
BibTeX
@article{mecfsatlas-al-mouslmani-2025-characterization-postural,
author = {Al Mouslmani, Mohammad and Sawano, Mitsuaki and Arun, Adith S and Wu, Yilun and Shah, Rishi M and Kaleem, Shayaan and Zhou, Tianna and Murugiah, Karthik and Lu, Yuan and Herrin, Jeph and Bishop, Pamela and Taub, Pam and Peixoto, Aldo J and Bhattacharjee, Bornali and Iwasaki, Akiko and Krumholz, Harlan M},
title = {Characterization of Postural Orthostatic Tachycardia Syndrome in Long COVID: Self-reported Data From the LISTEN Study.},
journal = {JACC. Advances},
year = {2025},
doi = {10.1016/j.jacadv.2025.101873},
note = {PubMed: 40883051},
url = {https://www.mecfsatlas.com/evidence/al-mouslmani-2025-characterization-postural},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-25. https://www.mecfsatlas.com/evidence/al-mouslmani-2025-characterization-postural
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