Start Here
A guide to the ME/CFS Atlas
The atlas is a structured evidence reference for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Every study is classified by evidence level, diagnostic criteria, and post-exertional malaise status — so you can see how strong the evidence is before trusting it.
Read these first
Three short guides cover the foundation. If you only read a few things on the atlas, read these.
What is ME/CFS?
The disease itself: core features, triggers, severity, and the state of the biomedical evidence.
Read →What is PEM?
Post-exertional malaise — the defining feature of ME/CFS. Delayed, disproportionate symptom worsening after exertion.
Read →Why criteria matter
Different diagnostic criteria identify different patient groups. Why PEM-required criteria produce stronger research.
Read →Three ways to use the atlas
Browse by topic
15 research domains with structured synthesis of what is known, uncertain, and emerging. Start here if you want an overview.
/research →Search the evidence
Filter classified studies by evidence level, diagnostic criteria, PEM status, and research domain. Every entry links to the original paper.
/evidence →Ask the Atlas
Evidence-grounded answers with study citations. Best for specific questions. Answers are explicit about what is established, uncertain, or emerging.
/chat →Paths by situation
Curated reading paths for specific situations. Each path leads to a short sequence of studies and guides.
I'm newly diagnosed
Find grounded, clear answers to start understanding what ME/CFS means for you.
I think I may have ME/CFS
Understand the symptoms and diagnostic criteria before your next appointment.
I want to understand PEM
Deep dive into post-exertional malaise — the central, defining feature of ME/CFS.
I need practical daily help
Strategies, tools, and evidence-based approaches for managing day-to-day life.
I want research I can trust
Explore the evidence base — structured, rated, and annotated for quality.
I'm severe or mostly bedbound
Short, accessible reads about severe ME/CFS — no long articles required.
I'm a family member or partner
Understand what your loved one is experiencing — and how to support them.
I'm a clinician
Structured evidence, diagnostic criteria, and clinical guidance grounded in current research.
I'm a researcher
Annotated study collections, paradigm mapping, and methodology notes for serious investigation.