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The science matters — and you deserve to read it without having to decode it yourself.
Guidance
- Check whether the study required post-exertional malaise for inclusion. Studies that don't require PEM may be studying chronic fatigue, not ME/CFS — these are fundamentally different populations.
- Look at sample size. Many ME/CFS studies are small (under 50 participants), which limits what conclusions can be drawn.
- Notice the research paradigm. Studies framed around deconditioning or illness beliefs approach ME/CFS very differently from those investigating immune, metabolic, or neurological mechanisms.
- Check whether the control group is well-matched. Healthy controls may not be enough — some findings also need comparison with other fatiguing conditions.
If you read one thing
Deep dive · 10+ min
Evidence Atlas
Browse structured studies filtered by topic, evidence level, and paradigm.
Read this →Recommended reads
About ME/CFS Atlas
Quick read · 30 sec
How this atlas is built — our approach to evidence, clarity, and intellectual honesty.
What is ME/CFS?
Standard · 3 min
A science-grounded overview to anchor your reading of the evidence.
CBT/GET critique (Twisk 2009)
Standard · 3 min
A review of the evidence on CBT and GET — and why the paradigm debate matters.
More resources are available in the Atlas and Evidence sections.