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Updates

What's New in the Atlas

The atlas is continuously updated as new research is processed and reviewed. Entries shown here pass a quality filter — reviewed studies and machine drafts at E1/E2 evidence level. Each entry carries a review status label.

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Recently Added Studies

The latest studies added to the public atlas. Reviewed entries are shown first. Machine-drafted entries are filtered to E1/E2 evidence level only.

E2 ModeratePEM unclearPreliminaryCase-ControlMachine-drafted

Increased tenderness in the left third intercostal space in adult patients with myalgic encephalomyelitis: a controlled study.

Puri, B K, Gunatilake, K D R, Fernando, K A C et al.·The Journal of international medical research·2011

Researchers examined the chests of 42 people with ME/CFS and 20 healthy people to look for physical signs. They found that 81% of people with ME/CFS had tenderness (pain when touched) in a specific area on the left side of their rib cage, while none of the healthy people had this tenderness. This suggests there may be a consistent physical finding that doctors could potentially use to help identify ME/CFS.

E2 ModeratePEM unclearPreliminaryObservationalMachine-drafted

Search for an association between Epstein-Barr virus infection and the chronic fatigue syndrome.

Joncas, J H·Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada·1991

This study looked at whether Epstein-Barr virus (EBV), a common virus that causes mononucleosis, might be connected to ME/CFS. Researchers compared people with ME/CFS to other groups to see if they had different levels of EBV infection or antibodies. This was one of the early investigations into potential viral causes of ME/CFS.

Immune System
E2 ModeratePEM unclearPreliminaryObservationalMachine-drafted

Effect of noise stress on chronic fatigue syndrome patients.

Beh, H C·The Journal of nervous and mental disease·1997

This study looked at how noise affects people with ME/CFS, examining whether environmental sounds make their symptoms worse. The research observed how patients responded to noise stress as part of understanding the condition better. This type of research helps identify triggers that may worsen fatigue and other ME/CFS symptoms.

Pain and Sensitization
E1 ReplicatedPEM unclearPreliminaryRCTMachine-drafted

A small, randomized, placebo-controlled trial of the use of antiviral therapy for patients with chronic fatigue syndrome.

Lerner, A M, Zervos, M, Chang, C H et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2001

This study tested whether antiviral medications could help people with ME/CFS, since some researchers suspected a viral infection might be causing the illness. A small group of patients received either an antiviral drug or a placebo (inactive pill) to see if the medication improved their symptoms. This was one of the early attempts to test whether treating a possible underlying virus could help ME/CFS patients feel better.

E2 ModeratePEM unclearModerate confidenceCross-SectionalMachine-drafted

The Prevalence, Severity, and Impact of Post-COVID Persistent Fatigue, Post-Exertional Malaise, and Chronic Fatigue Syndrome.

Nehme, Mayssam, Chappuis, Francois, Kaiser, Laurent et al.·Journal of general internal medicine·2023

This study looked at how common long-lasting fatigue is in people who had COVID-19, and whether some of them developed ME/CFS (a serious fatigue illness). Researchers surveyed a large group of people to understand how severe their exhaustion was and how much it affected their daily lives. The findings help show how many COVID survivors experience ongoing tiredness that resembles ME/CFS.

Post-Exertional Malaise
E1 ReplicatedPEM unclearPreliminaryRCTMachine-drafted

[Experience of application of adaptol in treatment of chronic fatigue syndrome in patients with chronic cerebral ischemia].

Mokina, T V, Antipenko, E A, Gustov, A V·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2009

This study looked at whether a medication called adaptol might help people with chronic fatigue syndrome (ME/CFS) who also have reduced blood flow to the brain. Researchers gave some patients adaptol while others received a comparison treatment, and they measured changes in fatigue and other symptoms. The study suggests adaptol may have helped improve some symptoms in this specific group of patients.

E2 ModeratePEM unclearModerate confidenceCase-ControlMachine-drafted

Dysautonomia in chronic fatigue syndrome vs. fibromyalgia.

Rosner, I, Rozenbaum, M, Naschitz, J E et al.·The Israel Medical Association journal : IMAJ·2000

This study compared how the nervous systems of people with ME/CFS and fibromyalgia function differently, focusing on dysautonomia—problems with the automatic nervous system that controls heart rate, blood pressure, and other body functions. Researchers used a case-control design to examine whether these two conditions show distinct patterns of autonomic dysfunction. The findings help clarify whether ME/CFS and fibromyalgia are separate conditions with different underlying nervous system problems.

Autonomic Nervous System
E2 ModeratePEM unclearModerate confidenceCross-SectionalMachine-drafted

[Mapping of function in chronic fatigue syndrome].

Nyland, Harald, Næss, Halvor, Nyland, Morten·Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2015

This study examined how different body functions are affected in people with ME/CFS by mapping their characteristics across a group of patients. The research looked at various functional areas to better understand the pattern of symptoms and impairments experienced by those with the condition. This type of mapping helps clinicians and researchers see which functions are most commonly affected and how they relate to each other.

E2 ModeratePEM unclearPreliminaryObservationalMachine-drafted

Epstein-Barr antibody titer and chronic fatigue syndrome.

Powell, M A·Journal of the American Academy of Nurse Practitioners·1990

This study looked at whether people with ME/CFS have higher levels of antibodies against Epstein-Barr virus (a common virus that causes mononucleosis) compared to healthy people. Researchers measured these antibody levels in patients diagnosed with chronic fatigue syndrome to see if there was a connection between past or ongoing EBV infection and the development of ME/CFS.

Immune System
E2 ModeratePEM unclearModerate confidenceCross-SectionalMachine-drafted

Epidemiology of chronic fatigue syndrome and self reported myalgic encephalomyelitis in 5-15 year olds: cross sectional study.

Chalder, T, Goodman, R, Wessely, S et al.·BMJ (Clinical research ed.)·2003

This study looked at how common ME/CFS is in children aged 5-15 years old in the United Kingdom. Researchers surveyed thousands of families to find out how many children experienced long-lasting tiredness and muscle pain similar to ME/CFS. The findings help doctors understand how widespread this condition is in young people.

Recent Activity

Recent additions and corrections to the atlas record.

Apr 13, 2026—Revised: “Preventive Effects of Probiotic Formula on Metabolic Stress Associated Physical Fatigue in Forced Swimming and LPS-Induced Mouse Models.”
Apr 10, 2026—Revised: “A view of the violence contained in chronic fatigue syndrome.”
Apr 10, 2026—Revised: “Multi-Strain Probiotic Improves Tryptophan Metabolism and Symptoms in Chronic Fatigue Syndrome Patients with Co-Occurring Irritable Bowel Syndrome: An Open-Label Pilot Study.”
Apr 10, 2026—Revised: “Generating a Social Movement Online Community through an Online Discourse: The Case of Myalgic Encephalomyelitis.”
Apr 10, 2026—Revised: “Phylogenetic tree-based microbiome association test.”
Apr 10, 2026—Revised: “Dissociation of body-temperature and melatonin secretion circadian rhythms in patients with chronic fatigue syndrome.”
Apr 10, 2026—Revised: “Chronic fatigue syndrome therapies grounded in science hold promise.”
Apr 10, 2026—Revised: “Low-dose hydrocortisone for chronic fatigue syndrome.”
Apr 10, 2026—Revised: “The Family Response Questionnaire: a new scale to assess the responses of family members to people with chronic fatigue syndrome.”
Apr 10, 2026—Revised: “Markers of viral infection in monozygotic twins discordant for chronic fatigue syndrome.”

Atlas Stats

6113

studies in the public atlas

15

topics with synthesis

7807

raw research records in the corpus