Updates

What's New in the Atlas

The atlas is continuously updated as new research is ingested, classified, and summarised. Entries shown here pass a quality filter: strong evidence level (E0–E2), biomedical or neutral paradigm, and peer-reviewed source. Every study page carries a permanent disclosure that the summary is machine-drafted.

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Recently Added Studies

The latest studies added to the public atlas. Reviewed entries are shown first. Machine-drafted entries are filtered to E1/E2 evidence level only.

E0 ConsensusReviewPEM unclearReview-Narrative

[Recognizing and managing post-exertional malaise in primary care].

Garcia, Sara, Tzartzas, Konstantinos, von Plessen, Christian et al.·Revue medicale suisse·2026

This review article describes post-exertional malaise (PEM)—a pattern of symptom worsening that occurs after physical, cognitive, emotional, or social exertion—and discusses how primary care doctors can recognise and manage it. The authors note that PEM was first identified in ME/CFS but is now also observed in long COVID and other post-infectious conditions. Early detection and appropriate management are reported as important to prevent long-term functional decline, though this review does not provide evidence that specific treatments prevent such decline.

InterventionsDiagnosticsLong COVID OverlapPost-Exertional Malaise

E0 ConsensusReviewPEM not requiredSystematic-Review

Beyond the pelvis: redefining endometriosis as a systemic inflammatory disorder. A systematic review and meta-analysis.

Zheng, Sai-Hua, Gao, Shao-Jun, Cai, Jing-Jing et al.·Autoimmunity reviews·2026

This systematic review examined whether endometriosis—a condition in which tissue grows outside the uterus—is associated with other chronic illnesses affecting the whole body, including autoimmune diseases, allergies, pain syndromes, and thyroid disorders. Researchers analysed 55 published studies and found that women with endometriosis reported higher rates of conditions like lupus, Sjögren's syndrome, fibromyalgia, and chronic fatigue syndrome, though the overall quality of evidence was reported as low or very low.

Endocrine DisruptionPain and SensitizationImmune System

E0 ConsensusReviewPEM unclearReview-Narrative

The impact of creatine on brain functions.

Borowski, Tymoteusz, Zimoń, Maria, Piegza, Magdalena Justyna·Psychiatria polska·2026

This review examines how creatine—a natural compound the body uses for energy—might affect brain function and ME/CFS symptoms. The authors report that creatine supplementation was associated with improvements in cognitive performance under stress, potential mood benefits, and in some ME/CFS patients, reductions in pain and improvements in physical performance, though effects on overall fatigue remain unclear. However, the evidence is mixed, and much more research is needed before firm conclusions can be drawn.

Pain and SensitizationEnergy MetabolismInterventionsCognitive Impairment

E0 ConsensusReviewPEM unclearSystematic-Review

[An insight into the long/post COVID care situation in Germany-a rapid scoping review].

Ebster, Marlene, Gscheidle, Sonja, Lange, Saskia et al.·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2026

A German research team reviewed 44 published sources to map how long COVID and related conditions—including ME/CFS—are managed within Germany's healthcare system. They report that patients often encounter information gaps, unclear responsibilities, long waiting times, and sometimes receive advice to increase activity despite the risk of post-exertional malaise. The review is preliminary and describes the current situation; it does not evaluate whether specific treatments work or how to fix these gaps.

Diagnostics

E0 ConsensusReviewPEM unclearSystematic-Review

Measures of Overall Illness Severity and Burden for ME/CFS: A Scoping Review.

Cripe, Jada, Ravichandran, Suvetha, Deditz, Samantha et al.·The patient·2026

Researchers reviewed 190 published studies to map out which measurement tools are most commonly used to assess how severe ME/CFS is and how much it impacts patients' daily lives. The most frequently used tools were general health surveys (SF-36 and Sickness Impact Profile) and some disease-specific questionnaires, but the review found that these tools do not consistently measure the same things, and many fail to capture the core experience of post-exertional malaise. The authors conclude that a standardized, ME/CFS-specific measurement approach is needed, though this scoping review does not itself test or validate any new measurement tool.

DiagnosticsPost-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

Fatigue across physical and mental health conditions: results from a multicenter study at the German Center for Mental Health.

Erschens, R, Zipfel, S, Schröpel, C et al.·Journal of psychosomatic research·2026

Researchers compared fatigue levels across seven different conditions—including post-COVID, chronic pain, cancer, multiple sclerosis, inflammatory bowel disease, kidney failure, and ME/CFS—using the same measurement tools in 538 patients. They observed that fatigue burden varied substantially between conditions, with post-COVID, chronic pain, and cancer showing similar high levels, while inflammatory bowel disease showed lower levels. However, the study included only 25 ME/CFS patients, analysed descriptively rather than statistically, so findings specific to ME/CFS remain preliminary and require confirmation in larger cohorts.

Diagnostics

E2 ModerateCohortPEM unclearObservational

Exploratory clinical and immunological changes following Tixagevimab/Cilgavimab administration in immunodeficient patients with SARS-CoV-2-associated ME/CFS and persistent circulating spike protein.

Seidel, Maximilian, Anft, Moritz, Wiemers, Lea et al.·Immunology letters·2026

Researchers gave a monoclonal antibody treatment (Tixagevimab/Cilgavimab) to nine immunodeficient patients with long COVID and ME/CFS-like symptoms who had detectable coronavirus spike protein in their blood. After 30 days, one immune marker (β1-adrenergic receptor autoantibody) showed a modest decrease, but spike protein levels and symptom outcomes did not change significantly as a group. These are very preliminary findings from a small study without a control group, and the authors emphasise that efficacy remains uncertain.

BiomarkersInterventionsAutonomic Nervous SystemImmune System

E2 ModerateCohortPEM unclearCross-Sectional

FreeSurfer-based amygdala subfield volumetry in long COVID and ME/CFS: clinical and immunological correlations.

Kimura, Yukio, Sato, Wakiro, Shigemoto, Yoko et al.·Frontiers in neurology·2026

Researchers used high-resolution brain imaging to examine a small part of the brain called the amygdala in people with long COVID, ME/CFS, and healthy controls. They observed some differences in the size of specific amygdala regions between groups and found associations between these brain measurements and certain immune markers, but these findings were preliminary and did not remain significant after statistical correction for multiple comparisons. The study is exploratory and does not yet establish why these brain differences occur or whether they are clinically meaningful.

NeuroinflammationBiomarkersLong COVID Overlap

E2 ModerateCohortPEM unclearCross-Sectional

Epigenome-wide profiling identifies distinct DNA methylation architecture underlying ME/CFS and fibromyalgia symptom burden.

Polli, Andrea, Hendrix, Jolien, Wyns, Arne et al.·Journal of translational medicine·2026

Researchers compared blood cell DNA methylation (a chemical tag that regulates gene activity) in 71 people with ME/CFS, 44 with fibromyalgia, and 73 healthy controls. They found two distinct methylation patterns: one associated mainly with post-exertional malaise and cognitive symptoms in ME/CFS, and another associated with broader pain and sleep symptoms in both patient groups. This is one study in early-stage research; the findings have not yet been replicated in independent groups, and it remains unclear whether these methylation patterns could be used clinically to diagnose or monitor these conditions.

NeuroinflammationPain and SensitizationBiomarkersSleep

E2 ModerateCohortPEM unclearCross-Sectional

Muscle symptoms and a latent physiological symptom-dysregulation factor in ME/CFS: exploratory analyses by sex and age-defined menopausal-status proxy group.

Habermann-Horstmeier, Lotte, Horstmeier, Lukas M·Journal of translational medicine·2026

This cross-sectional study of 736 people with ME/CFS examined how muscle symptoms relate to other physiological symptoms and whether these patterns differ by sex and menopausal status. Researchers observed that muscle problems were associated with breathing difficulties, flu-like symptoms, temperature-regulation problems, and cardiovascular symptoms, and identified a shared underlying 'physiological dysregulation factor' that grouped these symptoms together. However, the study's exploratory analyses by sex and menopausal status produced descriptive patterns that were not statistically confirmed as true differences across groups, and the study cannot establish whether these associations reflect causation or mechanism.

Pain and SensitizationAutonomic Nervous SystemPost-Exertional Malaise

Recent Activity

Recent additions and corrections to the atlas record.

Oct 21, 2026—Revised: “[Recognizing and managing post-exertional malaise in primary care].”

Oct 21, 2026—Revised: “Beyond the pelvis: redefining endometriosis as a systemic inflammatory disorder. A systematic review and meta-analysis.”

Oct 19, 2026—Revised: “The impact of creatine on brain functions.”

Oct 18, 2026—Revised: “The metabolic debt model: cumulative bioenergetic burden and network vulnerability in brain disorders-a hypothesis article.”

Oct 17, 2026—Revised: “Identification of SGK1 as a candidate regulator associated with myeloid cell senescence in ME/CFS: An integrative transcriptomic and experimental study.”

Oct 17, 2026—Revised: “[An insight into the long/post COVID care situation in Germany-a rapid scoping review].”

Oct 16, 2026—Revised: “Post-acute sequelae of COVID-19 (PASC) are associated with distinct clinical phenotypes two years after SARS-CoV-2 infection: A data-driven approach.”

Oct 16, 2026—Revised: “Measures of Overall Illness Severity and Burden for ME/CFS: A Scoping Review.”

Oct 15, 2026—Revised: “Myalgic Encephalomyelitis/chronic fatigue syndrome: a critical narrative review of modern concepts and unani perspectives.”

Oct 13, 2026—Revised: “Which needs do children, adolescents, and young adults with ME/CFS and their parents express and feel? - Qualitative study in Germany.”

Atlas Stats

6208

studies in the public atlas

topics with synthesis

8044

raw research records in the corpus