Skip to content

Updates

What's New in the Atlas

The atlas is continuously updated as new research is ingested, classified, and summarised. Entries shown here pass a quality filter: strong evidence level (E0–E2), biomedical or neutral paradigm, and peer-reviewed source. Every study page carries a permanent disclosure that the summary is machine-drafted.

Stay updated

Get a weekly digest of new ME/CFS research added to the atlas. No spam, unsubscribe anytime.

We send one email per week. Your email is never shared.

Recently Added Studies

The latest studies added to the public atlas. Reviewed entries are shown first. Machine-drafted entries are filtered to E1/E2 evidence level only.

E2 ModerateCohortPEM unclearObservational

Association of rapamycin treatment with the modulation of purine metabolism, reduced microglial inflammatory responses, improved mitochondrial energy metabolism, and alleviation of fatigue symptoms in ME/CFS subjects: pilot findings from phase-II observational study.

Gile, Brooke, Bulbule, Sarojini, Toriola, Mubaraq A et al.·Journal of translational medicine·2026

A pilot study observed that people with ME/CFS who received low-dose rapamycin reported improvements in fatigue symptoms over 90 days, and blood tests showed changes in purine metabolism and mitochondrial energy markers. However, this was a small observational study without a placebo control group, so it does not yet establish whether rapamycin actually causes these improvements or whether the observed biochemical changes are responsible for symptom relief.

NeuroinflammationBiomarkersEnergy MetabolismInterventions
E2 ModerateCohortPEM unclearCross-Sectional

Differences in diagnostic coding in long COVID: sociodemographic and symptom interference factors.

Vickers, Jasmine K, Levitan, Emily B, Howell, Carrie R et al.·BMC infectious diseases·2026

Researchers surveyed 205 people with Long COVID to understand how severe symptoms interfere with daily life and whether their condition was formally recorded in medical records. They found that people reporting high symptom interference were more likely to be older, female, obese, or in poor general health—but among those with severe symptoms, having an official Long COVID diagnosis code in their medical record was not associated with these demographic factors. The study observed discrepancies between what patients reported and what appeared in their medical records, though researchers did not find evidence that doctors were coding the diagnosis based on demographic bias.

Diagnostics
E2 ModerateCohortPEM unclearCross-Sectional

Disrupted glymphatic function and its relationship with sleep and cognitive impairment in ME/CFS assessed via DTI-ALPS.

Thapaliya, Kiran, Marshall-Gradisnik, Sonya, Inderyas, Maira et al.·Frontiers in neuroscience·2026

Researchers used a brain imaging technique called DTI-ALPS to measure how well the brain clears waste during sleep in 31 ME/CFS patients and 27 healthy controls. They observed that ME/CFS patients had lower measurements than controls, and these measurements were associated with worse sleep disturbance and concentration problems. However, this is a preliminary study in a small group, and it remains unclear whether reduced glymphatic function actually causes ME/CFS symptoms or is simply correlated with them.

NeuroinflammationBiomarkersSleepCognitive Impairment
E2 ModerateCohortPEM unclearCross-Sectional

Association between light exposure patterns and multidimensional health outcomes in individuals with myalgic encephalomyelitis/chronic fatigue syndrome: findings from an observational cross-sectional cohort study.

Cambras, Trinitat, Domingo, Joan Carles, Sanmartín-Sentañes, Ramon et al.·Journal of translational medicine·2026

This study observed patterns of light exposure in 100 ME/CFS patients and 56 healthy controls over one week, using wrist-worn devices to track light, activity, and body temperature. Researchers found that ME/CFS patients with more stable daytime light exposure reported lower fatigue, better sleep, and higher quality of life compared to those with irregular or nighttime-dominant light patterns; these associations were not observed in healthy controls. The findings suggest light exposure patterns may be worth studying as a potentially modifiable lifestyle factor, though the study cannot prove that changing light exposure would improve symptoms.

BiomarkersInterventionsSleepAutonomic Nervous System
E0 ConsensusReviewPEM unclearReview-Narrative

Therapeutic plasma exchange and immunomodulatory strategies in post-infectious syndromes: A review of immune dysregulation in PTLDS, long COVID, ME/CFS, and PANS/PANDAS.

Kaplan, Gary·Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2026

This review examines whether immune system abnormalities in ME/CFS, long COVID, and related post-infectious conditions might respond to immune-modifying treatments such as plasma exchange and immunoglobulin therapy. The authors report that while some patients with specific immune markers showed improvements in observational studies, two large controlled trials (RituxME in ME/CFS and a TPE trial in long COVID) did not demonstrate benefit in unselected patient groups, suggesting that better ways to identify which patients might benefit are needed.

BiomarkersInterventionsSleepImmune System
E2 ModerateCohortPEM unclearCross-Sectional

Exploring differences in protein cargo of extracellular vesicles from ME/CFS patient plasma compared to healthy controls.

Rydland, Anne, Yran, Elena Støvring, Nyman, Tuula A et al.·Biochemistry and biophysics reports·2026

Researchers compared tiny particles called extracellular vesicles (EVs) in the blood of 49 ME/CFS patients and 50 healthy controls. They found that ME/CFS patients had higher concentrations of these particles, and 11 proteins inside them were observed at different levels in ME/CFS compared to controls—though these differences did not remain statistically significant after accounting for multiple comparisons. The study is exploratory and the authors note that further investigation is needed to understand whether these EV changes are relevant to ME/CFS.

BiomarkersImmune System
E0 ConsensusReviewPEM unclearReview-Narrative

Multimorbidity in Chronic Overlapping Pain Conditions: From Burden to Integrated Care.

d'Incau, Emmanuel, Kaplan, Chelsea Marie, Micoulaud-Franchi, Jean-Arthur et al.·Journal of clinical medicine·2026

This evidence map examines chronic overlapping pain conditions—a group of ten disorders including fibromyalgia, migraine, irritable bowel syndrome, and ME/CFS that frequently occur together in the same patients. Researchers observed that when multiple conditions coexist, patients report greater pain, worse sleep, more fatigue, and lower quality of life, along with fragmented care across many specialists. The review proposes that integrated screening and coordinated care might help, though effectiveness of these approaches remains to be tested.

NeuroinflammationPain and SensitizationInterventionsSleep
E2 ModerateCohortPEM unclearCross-Sectional

Comparative Gut Microbiome Alterations in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID-19 Syndrome.

Donchev, Deyan, Nikolova, Ralitsa, Vaseva, Katya et al.·Biomedicines·2026

Researchers compared gut bacteria in people with ME/CFS, long COVID, and healthy controls using stool samples. They observed that both ME/CFS and long COVID showed similar patterns of bacterial changes—including more of a bacterium called Sutterella and less of others—compared to healthy people, though the two conditions were not identical. The strongest links between bacterial patterns and symptoms were observed in fatigue and physical symptoms, though this is one study and findings require confirmation in larger follow-up research.

BiomarkersGut MicrobiomeEnergy MetabolismLong COVID Overlap
E2 ModerateCohortPEM unclearCross-Sectional

Symptom, Functional, and Work Participation Profiles Among Racialized Canadians with Pre-Existing Mental Health Challenges and Long COVID: A Cross-Sectional Study.

Shahzad, Maryam, Siddiqui, Sana, Lau, Chloe et al.·Healthcare (Basel, Switzerland)·2026

This study observed symptom burden, functional impairment, and mental health outcomes in 51 Canadian adults with long COVID who also identified as racialized and had pre-existing mental health conditions. Participants reported moderate overall symptoms, notable fatigue and post-exertional malaise, cognitive difficulties, and mild-to-moderate anxiety and depression, alongside moderate functional limitations in work, social, and daily activities. However, this is a small, self-selected group, and the findings may not generalise to all long COVID patients.

Cognitive ImpairmentLong COVID OverlapPost-Exertional Malaise
E0 ConsensusReviewPEM not requiredSystematic-Review

Effect of photobiomodulation on pain and quality of life in fibromyalgia syndrome: a systematic review.

G A, Swathi, Maiya, G Arun, Shetty, Shiran et al.·Lasers in medical science·2026

A systematic review of seven randomised controlled trials examined whether photobiomodulation therapy (a light-based treatment) could reduce pain and improve quality of life in fibromyalgia syndrome. The review reported short-term reductions in pain intensity and improvements in quality of life, sleep quality, and psychological well-being in study participants. However, the studies included were quite different from one another, which limits how widely these findings can be generalised; the authors note that larger, more standardised clinical trials are needed to clarify the actual role of this treatment.

Pain and SensitizationInterventionsSleep

Recent Activity

Recent additions and corrections to the atlas record.

Jul 12, 2026—Revised: “Clinical efficacy of Jianqiao ancient moxibustion in treating chronic fatigue syndrome: a single-center randomized controlled superiority trial protocol.”
Jul 12, 2026—Revised: “Association of rapamycin treatment with the modulation of purine metabolism, reduced microglial inflammatory responses, improved mitochondrial energy metabolism, and alleviation of fatigue symptoms in ME/CFS subjects: pilot findings from phase-II observational study.”
Jul 10, 2026—Revised: “Efficacy of acupuncture-based traditional Chinese medicine therapies for chronic fatigue syndrome: a systematic review and meta-analysis.”
Jul 10, 2026—Revised: “Hyperbaric oxygen alleviates CFS-like cognitive impairment via PLA2G4A-linked glycerophospholipid metabolism.”
Jul 9, 2026—Revised: “Telehealth-Based Ketogenic Metabolic Therapy With Lifestyle Interventions for Post-viral Illness: A Research Brief of Patients' Experiences.”
Jul 8, 2026—Revised: “Differences in diagnostic coding in long COVID: sociodemographic and symptom interference factors.”
Jul 7, 2026—Revised: “WIPButyrate produced by the Lycium ruthenicum polysaccharide alleviated sleep deprivation-induced chronic fatigue syndrome in mice through promoting microglial autophagy.”
Jul 6, 2026—Revised: “Disrupted glymphatic function and its relationship with sleep and cognitive impairment in ME/CFS assessed via DTI-ALPS.”
Jul 6, 2026—Revised: “Cognitive impairment and prefrontal TGF-β1 elevation in a rat model of fatigue.”
Jul 4, 2026—Revised: “Association between light exposure patterns and multidimensional health outcomes in individuals with myalgic encephalomyelitis/chronic fatigue syndrome: findings from an observational cross-sectional cohort study.”

Atlas Stats

6166

studies in the public atlas

15

topics with synthesis

7929

raw research records in the corpus