Amihăesei, Ioana Cristina, Cojocaru, Elena · Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi · 2014
ME/CFS is a serious illness marked by extreme tiredness that doesn't improve with rest, along with problems concentrating, pain, and worsening symptoms after activity. Diagnosis requires at least six months of severe fatigue plus four or more other specific symptoms. Current treatments focus on behavioral approaches and pacing rather than medications, though only about 5% of people fully recover, and more than half become unable to work.
This study helps validate ME/CFS as a distinct medical entity with objective diagnostic criteria, countering the historical dismissal of the condition. Understanding the established diagnostic framework and documented treatment approaches supports both patient recognition and clinical management discussions. The emphasis on severe occupational disability highlights the urgent need for better understanding and treatment options.
This review does not establish the underlying biological mechanisms or confirm causative factors, as the authors acknowledge that post-viral and stress hypotheses remain unverified. The study does not provide evidence comparing the efficacy of different treatment approaches, nor does it explain why recovery rates are so low. It also does not identify new diagnostic biomarkers or propose novel therapeutic interventions.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Amihăesei, Ioana Cristina & Cojocaru, Elena (2014). Main neuroendocrine features, diagnosis and therapeutic possibilities in the chronic fatigue syndrome, an underdiagnosed entity.. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi. https://pubmed.ncbi.nlm.nih.gov/25341286/
BibTeX
@article{mecfsatlas-amihesei-2014-main-neuroendocrine,
author = {Amihăesei, Ioana Cristina and Cojocaru, Elena},
title = {Main neuroendocrine features, diagnosis and therapeutic possibilities in the chronic fatigue syndrome, an underdiagnosed entity.},
journal = {Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi},
year = {2014},
note = {PubMed: 25341286},
url = {https://www.mecfsatlas.com/evidence/amihesei-2014-main-neuroendocrine},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/amihesei-2014-main-neuroendocrine
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