Asprusten, Tarjei Tørre, Fagermoen, Even, Sulheim, Dag et al. · Acta paediatrica (Oslo, Norway : 1992) · 2015 · DOI
Researchers tested whether the Canadian Consensus Criteria—a set of guidelines used to diagnose ME/CFS in teenagers—actually identify meaningful differences between patients. They compared 120 adolescents with ME/CFS, grouping them by whether they met these criteria or not. The study found that the two groups were nearly identical in most disease markers and how they recovered over time, suggesting the criteria may not be capturing important real-world differences between patients.
This study questions whether the Canadian Consensus Criteria—widely used diagnostic guidelines for adolescent ME/CFS—actually distinguish clinically meaningful subgroups. If the criteria don't identify real biological or prognostic differences, researchers and clinicians may need better diagnostic tools to identify which patients will recover and which may develop chronic illness.
This study does not prove the Canadian Consensus Criteria are clinically useless, only that they may lack content validity in this adolescent population. It does not establish what the criteria should measure or identify the optimal diagnostic approach for ME/CFS. The findings may not generalize to adult populations or patients selected under stricter inclusion criteria.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Asprusten, Tarjei Tørre, Fagermoen, Even, Sulheim, Dag, Skovlund, Eva, Sørensen, Øystein, Mollnes, Tom Eirik, et al. (2015). Study findings challenge the content validity of the Canadian Consensus Criteria for adolescent chronic fatigue syndrome.. Acta paediatrica (Oslo, Norway : 1992). https://doi.org/10.1111/apa.12950
BibTeX
@article{mecfsatlas-asprusten-2015-study-findings,
author = {Asprusten, Tarjei Tørre and Fagermoen, Even and Sulheim, Dag and Skovlund, Eva and Sørensen, Øystein and Mollnes, Tom Eirik and Wyller, Vegard Bruun},
title = {Study findings challenge the content validity of the Canadian Consensus Criteria for adolescent chronic fatigue syndrome.},
journal = {Acta paediatrica (Oslo, Norway : 1992)},
year = {2015},
doi = {10.1111/apa.12950},
note = {PubMed: 25640602},
url = {https://www.mecfsatlas.com/evidence/asprusten-2015-study-findings},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/asprusten-2015-study-findings
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