Barrioluengo, Verónica, Wang, Yi, Le Grice, Stuart F J et al. · The FEBS journal · 2012 · DOI
This study examined how accurately a virus called XMRV copies its genetic material when it infects human cells. Researchers compared XMRV's copying accuracy to two other viruses (HIV and another mouse virus) by measuring how often mistakes happen during the copying process. The study found that XMRV makes copies with reasonable accuracy, though with a different pattern of errors than HIV.
Understanding XMRV's replication fidelity is relevant to historical ME/CFS research because XMRV was once proposed as a potential causative agent. Accurate characterization of viral enzyme properties helps explain viral behavior and persistence patterns that were investigated in ME/CFS patients, even though XMRV's causal role has since been disputed.
This study does NOT prove that XMRV causes ME/CFS; indeed, the authors acknowledge evidence suggesting XMRV is unlikely to be causative. The study is purely mechanistic and does not involve patients, clinical outcomes, or any connection to ME/CFS disease pathology. It cannot establish whether XMRV's replication characteristics are relevant to any human disease.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Barrioluengo, Verónica, Wang, Yi, Le Grice, Stuart F J, & Menéndez-Arias, Luis (2012). Intrinsic DNA synthesis fidelity of xenotropic murine leukemia virus-related virus reverse transcriptase.. The FEBS journal. https://doi.org/10.1111/j.1742-4658.2012.08532.x
BibTeX
@article{mecfsatlas-barrioluengo-2012-intrinsic-dna,
author = {Barrioluengo, Verónica and Wang, Yi and Le Grice, Stuart F J and Menéndez-Arias, Luis},
title = {Intrinsic DNA synthesis fidelity of xenotropic murine leukemia virus-related virus reverse transcriptase.},
journal = {The FEBS journal},
year = {2012},
doi = {10.1111/j.1742-4658.2012.08532.x},
note = {PubMed: 22340433},
url = {https://www.mecfsatlas.com/evidence/barrioluengo-2012-intrinsic-dna},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/barrioluengo-2012-intrinsic-dna
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