Bedree, Helen, Sunnquist, Madison, Jason, Leonard A · Fatigue : biomedicine, health & behavior · 2019 · DOI
Researchers improved a questionnaire called the DSQ-2 that helps doctors identify and understand ME/CFS by asking patients about their specific symptoms. They tested this updated questionnaire with 399 people who have ME or CFS and found that it works well at measuring the main symptoms of these illnesses, including post-exertional malaise (feeling worse after activity), brain fog, pain, and sleep problems. The questionnaire is now a more reliable tool for both diagnosing ME/CFS and understanding how the illness affects different people.
Having a reliable, validated questionnaire is crucial for ensuring ME/CFS patients are accurately diagnosed and their symptoms are properly documented in clinical and research settings. This improved tool can help standardize how doctors and researchers assess ME/CFS, making it easier to identify patients, track symptom changes, and ensure consistency across studies and clinical practice.
This study validates that the DSQ-2 reliably measures symptoms—it does not prove what causes ME/CFS or how to treat it. The questionnaire's ability to measure symptoms also does not establish that everyone with these symptoms has ME/CFS, as other conditions may produce similar presentations. Additionally, this cross-sectional validation does not determine whether symptoms remain stable over time or how they change with different treatments.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Bedree, Helen, Sunnquist, Madison, & Jason, Leonard A (2019). The DePaul Symptom Questionnaire-2: A Validation Study.. Fatigue : biomedicine, health & behavior. https://doi.org/10.1080/21641846.2019.1653471
BibTeX
@article{mecfsatlas-bedree-2019-depaul-symptom,
author = {Bedree, Helen and Sunnquist, Madison and Jason, Leonard A},
title = {The DePaul Symptom Questionnaire-2: A Validation Study.},
journal = {Fatigue : biomedicine, health & behavior},
year = {2019},
doi = {10.1080/21641846.2019.1653471},
note = {PubMed: 32685281},
url = {https://www.mecfsatlas.com/evidence/bedree-2019-depaul-symptom},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/bedree-2019-depaul-symptom
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