Beretta, Pablo · Vertex (Buenos Aires, Argentina) · 2016
This study suggests that people with fibromyalgia and ME/CFS may have problems with how their muscles use oxygen. The authors found that patients' symptoms worsened in low-oxygen environments (like high altitudes or low air pressure) and improved with treatments that increase oxygen availability, including hyperbaric oxygen therapy and coenzyme Q10 supplements. Based on three patient cases that improved with medical oxygen treatment, the authors propose that oxygen therapy might help people experiencing severe symptom flare-ups.
Understanding oxygen metabolism in ME/CFS could identify a novel therapeutic target for acute exacerbations and unresponsive symptoms. This work bridges observations of environmental sensitivity in ME/CFS patients with potential mechanistic explanations and testable interventions, potentially offering relief options when standard treatments fail.
This study does not prove that oxygen deficiency causes ME/CFS or fibromyalgia, nor does it establish that medical oxygen is an effective treatment. The three case reports represent anecdotal evidence only; without randomized controlled trials, we cannot determine whether oxygen therapy works better than placebo or standard care, or whether symptom improvement was coincidental.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Beretta, Pablo (2016). [Fibromyalgia and myalgic encephalomyelitis: The oxygen clue].. Vertex (Buenos Aires, Argentina). https://pubmed.ncbi.nlm.nih.gov/28282079/
BibTeX
@article{mecfsatlas-beretta-2016-fibromyalgia-myalgic,
author = {Beretta, Pablo},
title = {[Fibromyalgia and myalgic encephalomyelitis: The oxygen clue].},
journal = {Vertex (Buenos Aires, Argentina)},
year = {2016},
note = {PubMed: 28282079},
url = {https://www.mecfsatlas.com/evidence/beretta-2016-fibromyalgia-myalgic},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/beretta-2016-fibromyalgia-myalgic
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