Blazquez, Alicia, Ruiz, Eva, Aliste, Luisa et al. · Journal of sex & marital therapy · 2015 · DOI
This study examined sexual problems in 615 women with ME/CFS and found that sexual dysfunction was more common in those with worse fatigue, more cognitive and nervous system symptoms, and co-occurring conditions like fibromyalgia or Sjögren's syndrome. The researchers used a validated questionnaire to measure sexual satisfaction and identified patterns linking symptom severity to sexual health problems. This suggests that ME/CFS symptoms directly impact intimate relationships and sexual function.
Sexual dysfunction is an understudied but clinically significant aspect of ME/CFS quality of life. This study provides quantitative evidence that sexual health problems are common and correlated with disease severity, highlighting an important dimension of symptom burden that clinicians should assess. Understanding these associations may improve holistic patient care and inform treatment priorities.
This study cannot prove that fatigue directly causes sexual dysfunction—only that they are associated. The cross-sectional design cannot establish whether symptom severity precedes sexual problems or vice versa. The study also does not identify the biological mechanisms linking ME/CFS symptoms to sexual dysfunction, nor can it explain why some women with severe symptoms maintain normal sexual function.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Blazquez, Alicia, Ruiz, Eva, Aliste, Luisa, García-Quintana, Ana, & Alegre, José (2015). The effect of fatigue and fibromyalgia on sexual dysfunction in women with chronic fatigue syndrome.. Journal of sex & marital therapy. https://doi.org/10.1080/0092623X.2013.864370
BibTeX
@article{mecfsatlas-blazquez-2015-effect-fatigue,
author = {Blazquez, Alicia and Ruiz, Eva and Aliste, Luisa and García-Quintana, Ana and Alegre, José},
title = {The effect of fatigue and fibromyalgia on sexual dysfunction in women with chronic fatigue syndrome.},
journal = {Journal of sex & marital therapy},
year = {2015},
doi = {10.1080/0092623X.2013.864370},
note = {PubMed: 24274008},
url = {https://www.mecfsatlas.com/evidence/blazquez-2015-effect-fatigue},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-27. https://www.mecfsatlas.com/evidence/blazquez-2015-effect-fatigue
Contribute
Private, reviewed by a human. Not a public comment thread.