Brito, Emanuella M, Bonifanti, Leonardo, Patel, Rajvi et al. · Cureus · 2025 · DOI
This review looked at studies testing whether vitamins, minerals, and dietary changes help ME/CFS patients feel less exhausted. Researchers found that a few supplements—like NADH, CoQ10, wasabi, and probiotics—showed promise in improving symptoms. However, many studies didn't use standardized ways to measure improvement, making it hard to compare results fairly across different research.
ME/CFS currently lacks approved treatments, and many patients seek symptom relief through supplements. This review identifies which nutritional interventions have research support and highlights the need for better study standardization, helping patients and clinicians make more informed decisions while guiding future research priorities.
This systematic review does not prove that these supplements are definitively effective—it only identifies promising candidates requiring further rigorous testing. The lack of standardized measurement tools means the observed improvements may not be directly comparable across studies, and causation cannot be established from this review alone. Individual patient responses may vary significantly.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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Primary citation
Brito, Emanuella M, Bonifanti, Leonardo, Patel, Rajvi, Jimenez, Jailene, Junco, Jacqueline, Rozenfeld, Irina R, et al. (2025). Nutraceutical Supplementation Effects on Subjective Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Systematic Review.. Cureus. https://doi.org/10.7759/cureus.87178
BibTeX
@article{mecfsatlas-brito-2025-nutraceutical-supplementation,
author = {Brito, Emanuella M and Bonifanti, Leonardo and Patel, Rajvi and Jimenez, Jailene and Junco, Jacqueline and Rozenfeld, Irina R and Renesca, Violetta and Cheema, Amanpreet K},
title = {Nutraceutical Supplementation Effects on Subjective Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Systematic Review.},
journal = {Cureus},
year = {2025},
doi = {10.7759/cureus.87178},
note = {PubMed: 40755709},
url = {https://www.mecfsatlas.com/evidence/brito-2025-nutraceutical-supplementation},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/brito-2025-nutraceutical-supplementation
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