Chronic fatigue syndrome: a personalized integrative medicine approach.

Observed Findings

• ME/CFS is recognized as a heterogeneous disorder with diverse etiological factors and multiple pathological features
• Multiple physiological domains are potentially involved, including mitochondrial function, immune dysfunction, inflammation, oxidative stress, nutritional deficiencies, and gastrointestinal disturbances
• Current standard treatments offer only modest benefits and prognosis remains poor
• A patient-centered framework based on modifiable physiological and environmental factors is proposed as potentially more effective than one-size-fits-all approaches
• Subgroups of patients may respond preferentially to specific targeted interventions

Inferred Conclusions

• A personalized, integrative medicine approach targeting individual physiological abnormalities and environmental factors may offer more effective management than current standard treatments
• Identifying and addressing modifiable factors specific to each patient could improve clinical outcomes and prognosis
• Future research and clinical practice should adopt individualized frameworks to match treatments to patient-specific pathophysiology
• This approach may enable identification of patient subgroups most likely to benefit from specific interventions

Remaining Questions