Bruton, Alisha, Fuller, Leslie · The Permanente journal · 2019 · DOI
This report describes one woman who had both a rare movement disorder (paroxysmal kinesigenic dyskinesia) and chronic fatigue syndrome. When she received weekly injections of vitamins and minerals, her movement disorder symptoms almost completely went away, and she was able to return to her normal daily activities. Genetic testing found several mutations that may help explain why this treatment worked so well for her.
This case is relevant to ME/CFS patients because it describes a comorbid presentation and explores whether micronutrient supplementation may help manage symptoms in patients with certain genetic profiles. For researchers, it raises questions about potential metabolic or genetic factors that could underlie symptom severity in ME/CFS and suggests parenteral nutrition as a potential therapeutic avenue worth investigating in controlled studies.
This single case report cannot prove that parenteral vitamins and minerals are an effective treatment for ME/CFS or PKD in general populations. It does not establish causation—the improvement could be due to placebo effect, natural disease fluctuation, or other concurrent changes. The genetic mutations identified are correlational findings that do not definitively explain the treatment mechanism, and results from one patient cannot be generalized to others.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Bruton, Alisha & Fuller, Leslie (2019). Paroxysmal Kinesigenic Dyskinesia Symptoms Markedly Reduced with Parenteral Vitamins and Minerals: A Case Report.. The Permanente journal. https://doi.org/10.7812/TPP/19.036
BibTeX
@article{mecfsatlas-bruton-2019-paroxysmal-kinesigenic,
author = {Bruton, Alisha and Fuller, Leslie},
title = {Paroxysmal Kinesigenic Dyskinesia Symptoms Markedly Reduced with Parenteral Vitamins and Minerals: A Case Report.},
journal = {The Permanente journal},
year = {2019},
doi = {10.7812/TPP/19.036},
note = {PubMed: 31634116},
url = {https://www.mecfsatlas.com/evidence/bruton-2019-paroxysmal-kinesigenic},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-25. https://www.mecfsatlas.com/evidence/bruton-2019-paroxysmal-kinesigenic
Contribute
Private, reviewed by a human. Not a public comment thread.