Castro-Marrero, Jesús, Domingo, Joan Carles, Cordobilla, Begoña et al. · Antioxidants & redox signaling · 2022 · DOI
This study tested whether taking Coenzyme Q10 and selenium supplements together could help ME/CFS patients feel better. Twenty-seven patients took these supplements daily for 8 weeks, and researchers measured their fatigue, quality of life, sleep, and blood markers related to stress and inflammation. The supplements improved overall fatigue and quality of life, and blood tests showed reduced oxidative stress and inflammation, though sleep did not improve.
ME/CFS lacks proven disease-modifying treatments, and understanding the role of oxidative stress and inflammation is critical. This study provides preliminary evidence that targeting these pathways with combined antioxidant supplementation may offer symptomatic benefit, offering a potential therapeutic avenue worth further investigation in larger controlled trials.
This study does not prove that CoQ10 plus selenium is an effective treatment for ME/CFS because it lacked a control group and used an open-label design, making it vulnerable to placebo effects. The small sample size (n=27) and short duration (8 weeks) mean results may not generalize to larger populations or long-term use. Correlation between biomarker changes and symptom improvement does not establish causation.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Castro-Marrero, Jesús, Domingo, Joan Carles, Cordobilla, Begoña, Ferrer, Roser, Giralt, Marina, Sanmartín-Sentañes, Ramon, et al. (2022). Does Coenzyme Q10 Plus Selenium Supplementation Ameliorate Clinical Outcomes by Modulating Oxidative Stress and Inflammation in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?. Antioxidants & redox signaling. https://doi.org/10.1089/ars.2022.0018
BibTeX
@article{mecfsatlas-castro-marrero-2022-does-coenzyme,
author = {Castro-Marrero, Jesús and Domingo, Joan Carles and Cordobilla, Begoña and Ferrer, Roser and Giralt, Marina and Sanmartín-Sentañes, Ramon and Alegre-Martín, Jose},
title = {Does Coenzyme Q10 Plus Selenium Supplementation Ameliorate Clinical Outcomes by Modulating Oxidative Stress and Inflammation in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?},
journal = {Antioxidants & redox signaling},
year = {2022},
doi = {10.1089/ars.2022.0018},
note = {PubMed: 35229657},
url = {https://www.mecfsatlas.com/evidence/castro-marrero-2022-does-coenzyme},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/castro-marrero-2022-does-coenzyme
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