Ciregia, F, Kollipara, L, Giusti, L et al. · Translational psychiatry · 2016 · DOI
This study looked at proteins in the mitochondria—the energy-producing structures in cells—to see if they differ in people with ME/CFS compared to healthy people. Researchers found that two specific proteins (ATPB and ACON) were higher in people with ME/CFS, suggesting these could potentially be useful markers to help identify the condition. The findings also hint that different subgroups of ME/CFS patients may have different protein patterns, which could eventually lead to more personalized treatments.
This work contributes to growing evidence that mitochondrial dysfunction may underlie ME/CFS pathophysiology, offering potential diagnostic biomarkers that are noninvasive (saliva-based). The observation that different CFS patients show different protein patterns supports the emerging concept that ME/CFS comprises biologically distinct subgroups, which could enable future stratified diagnosis and targeted treatment development.
This study does not prove that elevated ATPB and ACON cause ME/CFS or that these proteins are causally linked to fatigue generation—correlation and mechanism remain unknown. It also does not establish whether these proteins represent a stable diagnostic marker across time, different tissues, or disease stages. The study cannot determine clinical utility for diagnosis without prospective validation and receiver-operating-characteristic analysis.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Ciregia, F, Kollipara, L, Giusti, L, Zahedi, R P, Giacomelli, C, Mazzoni, M R, et al. (2016). Bottom-up proteomics suggests an association between differential expression of mitochondrial proteins and chronic fatigue syndrome.. Translational psychiatry. https://doi.org/10.1038/tp.2016.184
BibTeX
@article{mecfsatlas-ciregia-2016-bottom-proteomics,
author = {Ciregia, F and Kollipara, L and Giusti, L and Zahedi, R P and Giacomelli, C and Mazzoni, M R and Giannaccini, G and Scarpellini, P and Urbani, A and Sickmann, A and Lucacchini, A and Bazzichi, L},
title = {Bottom-up proteomics suggests an association between differential expression of mitochondrial proteins and chronic fatigue syndrome.},
journal = {Translational psychiatry},
year = {2016},
doi = {10.1038/tp.2016.184},
note = {PubMed: 27676445},
url = {https://www.mecfsatlas.com/evidence/ciregia-2016-bottom-proteomics},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/ciregia-2016-bottom-proteomics
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