Crichton, Alison, Knight, Sarah, Oakley, Ed et al. · Pediatrics · 2015 · DOI
Fatigue is a major problem for children with chronic illnesses, but doctors use many different tools to measure it. This review looked at 20 different fatigue assessment tools used in 89 studies across 14 health conditions, including ME/CFS and cancer. The researchers found that only two tools were truly reliable and could be used across different conditions, and more research is needed to better measure fatigue in younger children.
For ME/CFS patients and researchers, this review is important because it identifies and evaluates the fatigue measurement tools available for pediatric ME/CFS populations and highlights the significant gap in validated assessment instruments. Understanding which tools are reliable helps clinicians and researchers better measure treatment response and disease severity in children with ME/CFS. The finding that most instruments lack strong evidence suggests urgent need for improved fatigue assessment tools specifically designed for ME/CFS in children.
This review does not establish causation or mechanisms of fatigue in any condition—it only examines assessment tools, not why fatigue occurs or how to treat it. It does not prove that any particular fatigue instrument is superior for ME/CFS specifically, only that evidence quality is generally low across conditions. The review's focus on children under 18 means findings do not generalize to adult populations with ME/CFS.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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Primary citation
Crichton, Alison, Knight, Sarah, Oakley, Ed, Babl, Franz E, & Anderson, Vicki (2015). Fatigue in child chronic health conditions: a systematic review of assessment instruments.. Pediatrics. https://doi.org/10.1542/peds.2014-2440
BibTeX
@article{mecfsatlas-crichton-2015-fatigue-child,
author = {Crichton, Alison and Knight, Sarah and Oakley, Ed and Babl, Franz E and Anderson, Vicki},
title = {Fatigue in child chronic health conditions: a systematic review of assessment instruments.},
journal = {Pediatrics},
year = {2015},
doi = {10.1542/peds.2014-2440},
note = {PubMed: 25802352},
url = {https://www.mecfsatlas.com/evidence/crichton-2015-fatigue-child},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/crichton-2015-fatigue-child
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