Dos Santos, Erison Santana, Pérez-de-Oliveira, Maria Eduarda, Normando, Ana Gabriela Costa et al. · Head & neck · 2022 · DOI
This review looked at whether people with certain long-term health conditions—including chronic fatigue syndrome (ME/CFS)—are at higher risk for developing oral squamous cell carcinoma (a type of mouth cancer). Researchers analyzed data from over 1 million patients worldwide and found that people with ME/CFS, along with several rare genetic conditions and those who had bone marrow transplants, do have an increased risk. The study suggests doctors should pay special attention to mouth health in patients with these conditions.
This study is important because it identifies ME/CFS as a systemic condition associated with increased oral cancer risk, potentially prompting targeted screening protocols for this vulnerable population. For ME/CFS researchers, this finding adds to the growing body of evidence that ME/CFS involves systemic dysfunction beyond fatigue, specifically affecting cancer surveillance and immune health. The results could inform clinical care guidelines and highlight a previously under-recognized complication requiring patient awareness.
This study does not prove that ME/CFS directly causes oral cancer or explain the biological mechanism linking them. It is a prevalence analysis without controls or longitudinal follow-up; correlation alone does not establish causation, and unmeasured confounders (smoking, alcohol use, HPV exposure) may explain the association. The study also does not establish whether ME/CFS-specific pathophysiology or secondary effects drive the increased risk.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Dos Santos, Erison Santana, Pérez-de-Oliveira, Maria Eduarda, Normando, Ana Gabriela Costa, Gueiros, Luiz Alcino Monteiro, Rogatto, Silvia Regina, Vargas, Pablo Agustin, et al. (2022). Systemic conditions associated with increased risk to develop oral squamous cell carcinoma: Systematic review and meta-analysis.. Head & neck. https://doi.org/10.1002/hed.27193
BibTeX
@article{mecfsatlas-dos-santos-2022-systemic-conditions,
author = {Dos Santos, Erison Santana and Pérez-de-Oliveira, Maria Eduarda and Normando, Ana Gabriela Costa and Gueiros, Luiz Alcino Monteiro and Rogatto, Silvia Regina and Vargas, Pablo Agustin and Lopes, Márcio Ajudarte and da Silva Guerra, Eliete Neves and Leme, Adriana Franco Paes and Santos-Silva, Alan Roger},
title = {Systemic conditions associated with increased risk to develop oral squamous cell carcinoma: Systematic review and meta-analysis.},
journal = {Head & neck},
year = {2022},
doi = {10.1002/hed.27193},
note = {PubMed: 36114663},
url = {https://www.mecfsatlas.com/evidence/dos-santos-2022-systemic-conditions},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/dos-santos-2022-systemic-conditions
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