Durlach, J, Pagès, N, Bac, P et al. · Magnesium research · 2005
This paper proposes that low magnesium levels combined with disrupted biological clocks (your body's natural 24-hour rhythm) may contribute to asthma that gets worse at night. The authors suggest that magnesium depletion is different from simple magnesium deficiency—it involves a deeper dysregulation that cannot be fixed by supplements alone. They propose two subtypes based on whether the biological clock is overactive (linked to nighttime asthma) or underactive (linked to daytime symptoms).
ME/CFS patients frequently experience circadian dysfunction, magnesium depletion, and comorbid sleep disturbances. This framework linking magnesium status to biological clock dysregulation could help explain the circadian pathology observed in ME/CFS and inform treatment strategies beyond simple supplementation. The distinction between magnesium depletion and deficiency is particularly relevant, as many ME/CFS patients report inadequate response to standard supplementation.
This study does not prove causation—it presents a theoretical hypothesis without presenting original experimental data in the abstract. It does not establish that magnesium depletion causes asthma or ME/CFS, only proposes a potential mechanistic link. The paper does not provide clinical trial evidence that the proposed therapies (light therapy, darkness therapy, magnesium correction) are effective for these conditions.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Durlach, J, Pagès, N, Bac, P, Bara, M, & Guiet-Bara, A (2005). Magnesium depletion with hypo- or hyper- function of the biological clock may be involved in chronopathological forms of asthma.. Magnesium research. https://pubmed.ncbi.nlm.nih.gov/15945613/
BibTeX
@article{mecfsatlas-durlach-2005-magnesium-depletion,
author = {Durlach, J and Pagès, N and Bac, P and Bara, M and Guiet-Bara, A},
title = {Magnesium depletion with hypo- or hyper- function of the biological clock may be involved in chronopathological forms of asthma.},
journal = {Magnesium research},
year = {2005},
note = {PubMed: 15945613},
url = {https://www.mecfsatlas.com/evidence/durlach-2005-magnesium-depletion},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/durlach-2005-magnesium-depletion
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