Fulle, S, Mecocci, P, Fanó, G et al. · Free radical biology & medicine · 2000 · DOI
Researchers examined muscle tissue from ME/CFS patients and found signs of oxidative damage—a type of cellular wear and tear similar to rust forming on metal. The patients' muscles showed damage to DNA and fats in cells, and their bodies had ramped up production of protective chemicals called antioxidants to fight back against this damage. This suggests ME/CFS may cause real, measurable changes in how muscle cells function at a chemical level.
This study provides biochemical evidence that ME/CFS involves real, detectable changes in muscle tissue—not purely psychological or psychosomatic dysfunction. Identifying oxidative stress as a mechanism offers potential targets for future therapeutic interventions and validates the organic nature of the disease for patients and clinicians.
This study does not establish whether oxidative stress is the primary cause of ME/CFS or a secondary consequence of the disease. It also does not prove that targeting antioxidants would improve symptoms, nor does it clarify whether these muscle changes are reversible or whether they correlate with specific symptoms like post-exertional malaise.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Fulle, S, Mecocci, P, Fanó, G, Vecchiet, I, Vecchini, A, Racciotti, D, et al. (2000). Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome.. Free radical biology & medicine. https://doi.org/10.1016/s0891-5849(00)00419-6
BibTeX
@article{mecfsatlas-fulle-2000-specific-oxidative,
author = {Fulle, S and Mecocci, P and Fanó, G and Vecchiet, I and Vecchini, A and Racciotti, D and Cherubini, A and Pizzigallo, E and Vecchiet, L and Senin, U and Beal, M F},
title = {Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome.},
journal = {Free radical biology & medicine},
year = {2000},
doi = {10.1016/s0891-5849(00)00419-6},
note = {PubMed: 11118815},
url = {https://www.mecfsatlas.com/evidence/fulle-2000-specific-oxidative},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/fulle-2000-specific-oxidative
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