Güttes, Moritz, Lucio, Marianna, Skornia, Adam et al. · Scientific reports · 2024 · DOI
Researchers tested whether people with Post-COVID syndrome have slower reaction times when responding to visual stimuli shown in virtual reality glasses. They found that Post-COVID patients were indeed slower and less accurate at this task compared to healthy controls, suggesting this test might be a useful tool for identifying Post-COVID cognitive problems in the future.
Post-COVID syndrome lacks objective diagnostic tests, making it difficult for clinicians to confirm diagnosis. Finding a reliable, technology-based objective measure could help validate patient symptoms, improve clinical recognition, and standardize future research on Post-COVID cognitive dysfunction.
This study does not prove that the reaction time deficit is caused by direct viral damage to the nervous system, nor does it establish that the test is sensitive or specific enough for clinical diagnosis. The study is cross-sectional, so it cannot determine whether reaction time deficits persist, improve, or worsen over time in Post-COVID patients.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Güttes, Moritz, Lucio, Marianna, Skornia, Adam, Rühl, Eva, Steußloff, Fritz, Zott, Julia, et al. (2024). A case-control study of reaction time deficits in a 3D virtual reality in patients with Post-COVID syndrome.. Scientific reports. https://doi.org/10.1038/s41598-024-76827-7
BibTeX
@article{mecfsatlas-gttes-2024-case-control,
author = {Güttes, Moritz and Lucio, Marianna and Skornia, Adam and Rühl, Eva and Steußloff, Fritz and Zott, Julia and Mardin, Christian and Mehringer, Wolfgang and Ganslmayer, Marion and Michelson, Georg and Hohberger, Bettina},
title = {A case-control study of reaction time deficits in a 3D virtual reality in patients with Post-COVID syndrome.},
journal = {Scientific reports},
year = {2024},
doi = {10.1038/s41598-024-76827-7},
note = {PubMed: 39516496},
url = {https://www.mecfsatlas.com/evidence/gttes-2024-case-control},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/gttes-2024-case-control
Contribute
Private, reviewed by a human. Not a public comment thread.