Guignat, Laurence, Proust-Lemoine, Emmanuelle, Reznik, Yves et al. · Annales d'endocrinologie · 2017 · DOI
This guideline explains how people with adrenal insufficiency (a condition where the body cannot make enough cortisol) should be monitored by their doctors and what they should learn to manage their condition safely. Patients need regular check-ups, should learn how to recognize warning signs of a crisis, know how to adjust their medication, and be able to give themselves emergency injections. The guideline emphasizes helping patients become independent in managing their illness and mentions that special care programs may help people with chronic fatigue avoid taking too much cortisol replacement.
For ME/CFS patients, this guideline is relevant because some individuals have concurrent adrenal insufficiency or secondary adrenal dysfunction that may contribute to fatigue and exercise intolerance. Understanding proper monitoring and avoiding glucocorticoid over-replacement—explicitly mentioned in the abstract—is important for patients who may be managing both conditions, as excessive cortisol replacement can worsen fatigue and other symptoms.
This guideline does not establish the prevalence or diagnostic criteria for adrenal insufficiency in ME/CFS populations, nor does it prove that cortisol replacement is beneficial or harmful in ME/CFS specifically. It also does not present new clinical trial data comparing different monitoring or educational interventions, and it does not determine causality between adrenal dysfunction and chronic fatigue.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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Primary citation
Guignat, Laurence, Proust-Lemoine, Emmanuelle, Reznik, Yves, & Zenaty, Delphine (2017). Group 6. Modalities and frequency of monitoring of patients with adrenal insufficiency. Patient education.. Annales d'endocrinologie. https://doi.org/10.1016/j.ando.2017.10.009
BibTeX
@article{mecfsatlas-guignat-2017-group-modalities,
author = {Guignat, Laurence and Proust-Lemoine, Emmanuelle and Reznik, Yves and Zenaty, Delphine},
title = {Group 6. Modalities and frequency of monitoring of patients with adrenal insufficiency. Patient education.},
journal = {Annales d'endocrinologie},
year = {2017},
doi = {10.1016/j.ando.2017.10.009},
note = {PubMed: 29183634},
url = {https://www.mecfsatlas.com/evidence/guignat-2017-group-modalities},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/guignat-2017-group-modalities
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