[Post-COVID: An inventory focusing on the key complaints PEM and POTS].

Observed Findings

• Post-exertional malaise is reported in approximately 86% of long-COVID patients as a pattern of symptom intensification following exertion.
• Postural tachycardia syndrome, characterised by heart-rate and blood-pressure dysregulation on standing, is reported in approximately 82% of long-COVID patients.
• PEM and POTS are described as newly emergent after acute COVID-19 infection, distinguishing them from pre-existing conditions.
• Pacing and symptomatic management (pharmacological and non-pharmacological) are documented in the literature as approaches to managing these symptoms.
• Post-COVID symptoms more broadly are observed as nonspecific, diverse, and fluctuating.

Inferred Conclusions

• The authors interpret PEM and POTS as characteristic and typical of post-COVID disease when occurring de novo after infection.
• The authors propose that current scientific findings support an organic, SARS-CoV-2-driven basis for post-COVID symptoms, rather than a purely functional origin.
• The authors conclude that pacing represents a 'promising' therapeutic approach for PEM in long-COVID.
• The authors suggest that symptomatic, multimodal management (drug and non-drug) is the current standard approach to POTS in post-COVID.

Remaining Questions