Hill, W M · British journal of biomedical science · 1996
This review examines echoviruses, a family of common viruses that can cause outbreaks of illness around the world. The authors note that since polio has become rare, doctors have noticed more cases of non-polio enteroviruses (a related group of viruses) being linked to myalgic encephalomyelitis (ME) and post-viral fatigue syndrome. Different types of echoviruses tend to cause different patterns of illness in different populations.
This study is significant because it documents an epidemiological observation linking specific non-polio enteroviruses to ME/CFS and post-viral fatigue syndrome, suggesting a potential viral etiology for these conditions. Understanding which echovirus types are associated with ME/CFS could help researchers identify infectious triggers and develop targeted diagnostic or preventive strategies.
This review does not establish a definitive causal relationship between echoviruses and ME/CFS—it documents a temporal correlation in reported cases. The study does not provide mechanistic evidence for how echoviruses might trigger ME/CFS, nor does it quantify the proportion of ME/CFS cases attributable to echoviral infection. It cannot determine whether echovirus detection represents active infection, persistent infection, or incidental colonization in ME/CFS patients.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Hill, W M (1996). Are echoviruses still orphans?. British journal of biomedical science. https://pubmed.ncbi.nlm.nih.gov/8914350/
BibTeX
@article{mecfsatlas-hill-1996-echoviruses-still,
author = {Hill, W M},
title = {Are echoviruses still orphans?},
journal = {British journal of biomedical science},
year = {1996},
note = {PubMed: 8914350},
url = {https://www.mecfsatlas.com/evidence/hill-1996-echoviruses-still},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/hill-1996-echoviruses-still
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