Hiremath, Sonya, Doukrou, Montserrat, Flannery, Halina et al. · International journal of environmental research and public health · 2022 · DOI
This study looked at 27 children and teenagers with moderate to severe ME/CFS who stayed in a hospital and received coordinated care from multiple medical professionals. Most patients (85%) showed improvement in at least one important area of their lives, such as being able to move around better, return to school, sleep better, or enjoy social activities. These results suggest that hospital-based rehabilitation programs can help young people with severe ME/CFS improve their quality of life.
Children and adolescents with severe ME/CFS are an understudied population with limited published treatment outcome data. This study provides concrete evidence that multidisciplinary hospital-based rehabilitation can produce measurable improvements in functioning and quality of life, which is valuable for families, clinicians, and healthcare commissioners planning services for this vulnerable group.
This study does not prove that hospital-based rehabilitation is the most effective treatment for all children with ME/CFS, as there was no control group for comparison. The retrospective design means results depend on accurate medical record documentation, and outcomes cannot establish which specific components of the program drove improvements. Long-term sustainability of improvements and effects in milder cases remain unclear.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Hiremath, Sonya, Doukrou, Montserrat, Flannery, Halina, Carey, Catherine, Gregorowski, Anna, Ward, Joseph, et al. (2022). Key Features of a Multi-Disciplinary Hospital-Based Rehabilitation Program for Children and Adolescents with Moderate to Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ME/CFS.. International journal of environmental research and public health. https://doi.org/10.3390/ijerph192013608
BibTeX
@article{mecfsatlas-hiremath-2022-key-features,
author = {Hiremath, Sonya and Doukrou, Montserrat and Flannery, Halina and Carey, Catherine and Gregorowski, Anna and Ward, Joseph and Hargreaves, Dougal and Segal, Terry Yvonne},
title = {Key Features of a Multi-Disciplinary Hospital-Based Rehabilitation Program for Children and Adolescents with Moderate to Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ME/CFS.},
journal = {International journal of environmental research and public health},
year = {2022},
doi = {10.3390/ijerph192013608},
note = {PubMed: 36294186},
url = {https://www.mecfsatlas.com/evidence/hiremath-2022-key-features},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/hiremath-2022-key-features
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