Hsu, Chou-Yi, Ahmad, Irfan, Maya, Rana Warid et al. · Journal of translational medicine · 2025 · DOI
This review looked at how gut health might be connected to ME/CFS and found that people with ME/CFS often have different bacteria in their gut compared to healthy people. The researchers reviewed studies about various gut-focused treatments like probiotics, dietary changes, and other interventions that might help reduce ME/CFS symptoms by improving the gut-brain connection.
Understanding the gut-microbiome connection in ME/CFS could open new treatment pathways for a disease with limited therapeutic options. This review emphasizes that personalized microbiome-based interventions might reduce neuropsychiatric and physical symptoms, potentially improving quality of life for ME/CFS patients who currently have few evidence-based treatments.
This narrative review does not establish causation between dysbiosis and ME/CFS—only association—nor does it prove that any specific microbiome intervention is effective in treating ME/CFS. The review itself cannot validate clinical efficacy; it identifies promising directions requiring rigorous randomized controlled trials before clinical recommendations can be made.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Hsu, Chou-Yi, Ahmad, Irfan, Maya, Rana Warid, Abass, Mayada Ahmed, Gupta, Jitendra, Singh, Abhayveer, et al. (2025). The potential therapeutic approaches targeting gut health in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a narrative review.. Journal of translational medicine. https://doi.org/10.1186/s12967-025-06527-x
BibTeX
@article{mecfsatlas-hsu-2025-potential-therapeutic,
author = {Hsu, Chou-Yi and Ahmad, Irfan and Maya, Rana Warid and Abass, Mayada Ahmed and Gupta, Jitendra and Singh, Abhayveer and Joshi, Kamal Kant and Premkumar, J and Sahoo, Samir and Khosravi, Mohsen},
title = {The potential therapeutic approaches targeting gut health in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a narrative review.},
journal = {Journal of translational medicine},
year = {2025},
doi = {10.1186/s12967-025-06527-x},
note = {PubMed: 40350437},
url = {https://www.mecfsatlas.com/evidence/hsu-2025-potential-therapeutic},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/hsu-2025-potential-therapeutic
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