Hurt, Ryan T, Yadav, Siddhant, Schroeder, Darrell R et al. · Journal of primary care & community health · 2024 · DOI
This study surveyed over 500 Long COVID patients who received care at a specialized clinic about 2 years after their initial infection. While most patients reported that their symptoms improved compared to their first visit, only 4.5% felt they had fully recovered. Some treatments like low-dose naltrexone, vagal nerve stimulation, and fisetin were rated as helpful by a majority of patients who tried them.
This study provides real-world evidence of Long COVID's persistent burden and treatment response patterns in a specialized clinic setting. For ME/CFS patients, it demonstrates the challenge of achieving full recovery even with dedicated care, and identifies potentially beneficial interventions that warrant further investigation in controlled trials.
This study cannot establish causation or whether improvements resulted from clinic care itself versus natural recovery. The cross-sectional design with self-reported outcomes introduces bias, and small sample sizes for specific interventions limit conclusions about their true efficacy. The high response rate (62.9%) may not represent non-responders who were less engaged or more severely ill.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Hurt, Ryan T, Yadav, Siddhant, Schroeder, Darrell R, Croghan, Ivana T, Mueller, Michael R, Grach, Stephanie L, et al. (2024). Longitudinal Progression of Patients with Long COVID Treated in a Post-COVID Clinic: A Cross-Sectional Survey.. Journal of primary care & community health. https://doi.org/10.1177/21501319241258671
BibTeX
@article{mecfsatlas-hurt-2024-longitudinal-progression,
author = {Hurt, Ryan T and Yadav, Siddhant and Schroeder, Darrell R and Croghan, Ivana T and Mueller, Michael R and Grach, Stephanie L and Aakre, Christopher A and Gilman, Elizabeth A and Stephenson, Christopher R and Overgaard, Joshua and Collins, Nerissa M and Lawson, Donna K and Thompson, Ann M and Natividad, Lasonya T and Mohamed Elfadil, Osman and Ganesh, Ravindra},
title = {Longitudinal Progression of Patients with Long COVID Treated in a Post-COVID Clinic: A Cross-Sectional Survey.},
journal = {Journal of primary care & community health},
year = {2024},
doi = {10.1177/21501319241258671},
note = {PubMed: 38813984},
url = {https://www.mecfsatlas.com/evidence/hurt-2024-longitudinal-progression},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/hurt-2024-longitudinal-progression
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