Jason, L A, Richman, J A, Rademaker, A W et al. · Archives of internal medicine · 1999 · DOI
Researchers in Chicago called nearly 29,000 adults to find out how many people have ME/CFS. They found that about 0.42% of the general population has the condition—roughly 1 in 240 people. The study showed that ME/CFS affects women, minority groups, and people with lower education levels more often than previously thought, challenging the old idea that it mainly affected white middle-class people.
This study is important because it provides the first large-scale, community-based prevalence estimate of ME/CFS rather than relying on treated populations, which skew results based on healthcare access. The finding that ME/CFS affects women, minorities, and lower-income groups challenges historical biases in medical understanding and highlights disparities in disease recognition and access to diagnosis. This evidence supports the need for improved medical awareness and more equitable healthcare approaches across all demographic groups.
This study does not prove what causes ME/CFS or why certain demographic groups are more affected. It is cross-sectional, so it captures prevalence at one point in time but cannot determine disease incidence, prognosis, or how prevalence changes over time. The study also does not establish causal relationships between socioeconomic status, ethnicity, or sex and ME/CFS development—only that associations exist.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Jason, L A, Richman, J A, Rademaker, A W, Jordan, K M, Plioplys, A V, Taylor, R R, et al. (1999). A community-based study of chronic fatigue syndrome.. Archives of internal medicine. https://doi.org/10.1001/archinte.159.18.2129
BibTeX
@article{mecfsatlas-jason-1999-community-based,
author = {Jason, L A and Richman, J A and Rademaker, A W and Jordan, K M and Plioplys, A V and Taylor, R R and McCready, W and Huang, C F and Plioplys, S},
title = {A community-based study of chronic fatigue syndrome.},
journal = {Archives of internal medicine},
year = {1999},
doi = {10.1001/archinte.159.18.2129},
note = {PubMed: 10527290},
url = {https://www.mecfsatlas.com/evidence/jason-1999-community-based},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/jason-1999-community-based
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