Kang, Ji-Yun, Baek, Dong-Cheol, Lee, Jin-Seok et al. · BMC complementary medicine and therapies · 2025 · DOI
This study tested a herbal supplement called Myelophil (made from two traditional Korean medicinal plants) in mice that had high serotonin levels—a condition researchers believe may contribute to ME/CFS fatigue. Mice given Myelophil showed improvements in fatigue-related behaviors and pain sensitivity compared to untreated mice. The results suggest this supplement may help by adjusting how the brain handles serotonin.
This study provides preliminary mechanistic evidence that serotonergic dysregulation may contribute to ME/CFS-type fatigue and identifies a potential therapeutic target. If validated in humans, Myelophil could represent a novel treatment avenue for patients with ME/CFS, particularly those with evidence of serotonergic involvement. Understanding these mechanisms helps clarify biological underpinnings of central fatigue.
This animal model study does not prove that elevated serotonin causes ME/CFS in humans or that Myelophil will be effective in ME/CFS patients. The fluoxetine-induced mouse model mimics only one aspect of potential pathophysiology and may not capture the full complexity of the human disease. Rodent findings frequently do not translate to human clinical benefit.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Kang, Ji-Yun, Baek, Dong-Cheol, Lee, Jin-Seok, & Son, Chang-Gue (2025). Anti-central fatigue effects of myelophil in 5-HTergic hyperactivity mice model.. BMC complementary medicine and therapies. https://doi.org/10.1186/s12906-025-04882-2
BibTeX
@article{mecfsatlas-kang-2025-anti-central,
author = {Kang, Ji-Yun and Baek, Dong-Cheol and Lee, Jin-Seok and Son, Chang-Gue},
title = {Anti-central fatigue effects of myelophil in 5-HTergic hyperactivity mice model.},
journal = {BMC complementary medicine and therapies},
year = {2025},
doi = {10.1186/s12906-025-04882-2},
note = {PubMed: 40269903},
url = {https://www.mecfsatlas.com/evidence/kang-2025-anti-central},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/kang-2025-anti-central
Contribute
Private, reviewed by a human. Not a public comment thread.