Kempke, Stefan, Goossens, Lutgarde, Luyten, Patrick et al. · Journal of affective disorders · 2010 · DOI
This study followed 178 ME/CFS patients through a multi-component treatment program to identify which patient characteristics predicted who would improve. The researchers found that only depression severity before treatment started was associated with how fatigued patients remained after treatment—patients with higher depression were more likely to stay fatigued afterward. This suggests that addressing depression alongside other ME/CFS treatments may be important.
Depression is common in ME/CFS and often overlooked as a treatment target. This study provides empirical evidence that depression severity before treatment may influence treatment outcomes, suggesting that integrated approaches addressing both ME/CFS symptoms and depression could improve patient results.
This study does not prove that depression causes poor ME/CFS treatment outcomes or that treating depression will improve CFS outcomes—it only shows an association. The lack of a control group and long-term follow-up means we cannot determine if these results persist over time or compare treatment effects to natural recovery or placebo.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Kempke, Stefan, Goossens, Lutgarde, Luyten, Patrick, Bekaert, Patrick, Van Houdenhove, Boudewijn, & Van Wambeke, Peter (2010). Predictors of outcome in a multi-component treatment program for chronic fatigue syndrome.. Journal of affective disorders. https://doi.org/10.1016/j.jad.2010.01.073
BibTeX
@article{mecfsatlas-kempke-2010-predictors-outcome,
author = {Kempke, Stefan and Goossens, Lutgarde and Luyten, Patrick and Bekaert, Patrick and Van Houdenhove, Boudewijn and Van Wambeke, Peter},
title = {Predictors of outcome in a multi-component treatment program for chronic fatigue syndrome.},
journal = {Journal of affective disorders},
year = {2010},
doi = {10.1016/j.jad.2010.01.073},
note = {PubMed: 20167377},
url = {https://www.mecfsatlas.com/evidence/kempke-2010-predictors-outcome},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/kempke-2010-predictors-outcome
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