Krilov, L R · Pediatric annals · 1995 · DOI
This 1995 study examined chronic fatigue syndrome (ME/CFS) in children by comparing cases with controls. The research aimed to better understand how this condition affects young patients. As a case-control study, it looked at differences between children who had ME/CFS and those who didn't to identify important patterns.
This study is important because ME/CFS affects children and adolescents, yet pediatric cases were understudied in the early 1990s. Early clinical documentation of pediatric ME/CFS helped establish that this condition was not limited to adults and informed pediatrician recognition and management approaches.
This case-control study cannot establish causation or the underlying biological mechanisms of ME/CFS. The study design does not demonstrate whether observed differences between groups are primary features of the condition or secondary consequences, and findings may not generalize to all pediatric ME/CFS populations.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Krilov, L R (1995). Chronic fatigue syndrome.. Pediatric annals. https://doi.org/10.3928/0090-4481-19950601-05
BibTeX
@article{mecfsatlas-krilov-1995-chronic-fatigue,
author = {Krilov, L R},
title = {Chronic fatigue syndrome.},
journal = {Pediatric annals},
year = {1995},
doi = {10.3928/0090-4481-19950601-05},
note = {PubMed: 7659460},
url = {https://www.mecfsatlas.com/evidence/krilov-1995-chronic-fatigue},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/krilov-1995-chronic-fatigue
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