Kuratsune, H, Yamaguti, K, Hattori, H et al. · Nihon rinsho. Japanese journal of clinical medicine · 1992
This study examined 59 patients with ME/CFS to identify common symptoms and laboratory abnormalities. The main findings were that patients experienced prolonged fatigue after exercise, headaches, sleep problems, and mild fevers. Researchers found that ME/CFS patients had low levels of a substance called acylcarnitine in their muscles, which may help explain why their bodies struggle to produce energy and why they experience muscle pain and worsening symptoms after activity.
This study provided early evidence that ME/CFS involves measurable biochemical abnormalities rather than being purely psychological, helping establish it as a biological illness. The proposed acylcarnitine deficiency mechanism offers a potential explanation for core ME/CFS symptoms like postexertional malaise and fatigue, which could guide future treatment research.
This study does not prove that acylcarnitine deficiency causes ME/CFS, only that it is associated with the illness. The study cannot establish whether HHV-6 reactivation is a cause of ME/CFS or merely a consequence of immune dysfunction. Results from this Japanese population may not fully generalize to other ethnic or geographic populations.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Kuratsune, H, Yamaguti, K, Hattori, H, Tazawa, H, Takahashi, M, Yamanishi, K, et al. (1992). [Symptoms, signs and laboratory findings in patients with chronic fatigue syndrome].. Nihon rinsho. Japanese journal of clinical medicine. https://pubmed.ncbi.nlm.nih.gov/1337562/
BibTeX
@article{mecfsatlas-kuratsune-1992-symptoms-signs,
author = {Kuratsune, H and Yamaguti, K and Hattori, H and Tazawa, H and Takahashi, M and Yamanishi, K and Kitani, T},
title = {[Symptoms, signs and laboratory findings in patients with chronic fatigue syndrome].},
journal = {Nihon rinsho. Japanese journal of clinical medicine},
year = {1992},
note = {PubMed: 1337562},
url = {https://www.mecfsatlas.com/evidence/kuratsune-1992-symptoms-signs},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/kuratsune-1992-symptoms-signs
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