Lalremruta, Vanphawng, Prasanna, Gurunath S · Indian journal of pharmacology · 2012 · DOI
Researchers tested whether an extract from the leaves of a plant called Aegle marmelos (also known as bael fruit) could help reduce fatigue-like symptoms in rats. Rats that were forced to swim daily developed fatigue-like behaviors, and when treated with the plant extract, they showed improvement in activity levels, reduced anxiety, and better stress markers in their blood compared to untreated rats.
ME/CFS patients often experience significant fatigue and cognitive symptoms with limited treatment options. This research explores a natural compound that may address underlying oxidative stress, a mechanism implicated in some ME/CFS pathophysiology, potentially opening avenues for new therapeutic approaches.
This animal study does not prove that Aegle marmelos will be effective or safe in human ME/CFS patients. The forced swimming model only partially mimics human ME/CFS, and benefits seen in rats do not necessarily translate to humans. Additionally, the study does not establish the specific mechanisms by which the plant extract works or whether it targets the root causes of ME/CFS.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Lalremruta, Vanphawng & Prasanna, Gurunath S (2012). Evaluation of protective effect of Aegle marmelos Corr. in an animal model of chronic fatigue syndrome.. Indian journal of pharmacology. https://doi.org/10.4103/0253-7613.96316
BibTeX
@article{mecfsatlas-lalremruta-2012-evaluation-protective,
author = {Lalremruta, Vanphawng and Prasanna, Gurunath S},
title = {Evaluation of protective effect of Aegle marmelos Corr. in an animal model of chronic fatigue syndrome.},
journal = {Indian journal of pharmacology},
year = {2012},
doi = {10.4103/0253-7613.96316},
note = {PubMed: 22701245},
url = {https://www.mecfsatlas.com/evidence/lalremruta-2012-evaluation-protective},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/lalremruta-2012-evaluation-protective
Contribute
Private, reviewed by a human. Not a public comment thread.