Lattie, Emily G, Antoni, Michael H, Fletcher, Mary Ann et al. · Fatigue : biomedicine, health & behavior · 2013 · DOI
This study examined whether learning to manage stress could help people with ME/CFS feel less burdened by their illness, even if their symptoms don't improve. Researchers found that people who felt they had better stress management skills reported lower emotional distress and felt less limited in their daily activities and social life. Importantly, this benefit existed independently of how severe their ME/CFS symptoms were.
Many ME/CFS patients struggle with illness burden—the loss of ability to work, socialize, and manage daily tasks—which can be as disabling as the symptoms themselves. This research suggests that improving stress management skills through targeted interventions might help reduce this burden, offering a potentially actionable therapeutic approach that doesn't require symptom resolution to improve quality of life.
This study is correlational and cannot prove that stress management skills directly cause lower illness burden; both may be influenced by unmeasured factors. The cross-sectional design prevents establishing causal directionality, and findings do not demonstrate that stress management interventions will actually improve illness burden when applied in practice. The study also cannot determine whether stress management skills reduce emotional distress or whether people with lower emotional distress simply report having better stress management skills.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Lattie, Emily G, Antoni, Michael H, Fletcher, Mary Ann, Czaja, Sara, Perdomo, Dolores, Sala, Andreina, et al. (2013). Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Symptom Severity: Stress Management Skills are Related to Lower Illness Burden.. Fatigue : biomedicine, health & behavior. https://doi.org/10.1080/21641846.2013.843255
BibTeX
@article{mecfsatlas-lattie-2013-beyond-myalgic,
author = {Lattie, Emily G and Antoni, Michael H and Fletcher, Mary Ann and Czaja, Sara and Perdomo, Dolores and Sala, Andreina and Nair, Sankaran and Fu, Shih Hua and Penedo, Frank J and Klimas, Nancy},
title = {Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Symptom Severity: Stress Management Skills are Related to Lower Illness Burden.},
journal = {Fatigue : biomedicine, health & behavior},
year = {2013},
doi = {10.1080/21641846.2013.843255},
note = {PubMed: 24278791},
url = {https://www.mecfsatlas.com/evidence/lattie-2013-beyond-myalgic},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/lattie-2013-beyond-myalgic
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