Lau, Chi-ieong, Lin, Che-Chen, Chen, Wei-Hung et al. · Journal of psychosomatic research · 2015 · DOI
This study found that people with migraine headaches are 1.5 times more likely to develop ME/CFS than people without migraine. The risk was even higher in older adults (age 65+), who were more than twice as likely to develop ME/CFS if they had migraines. The more frequently someone had migraines, the higher their risk of developing ME/CFS appeared to be.
This study provides population-level epidemiological evidence that migraine and ME/CFS share a common underlying vulnerability rather than being coincidentally comorbid, suggesting shared biological mechanisms. Understanding this link may help clinicians recognize and better manage the migraine-CFS overlap, and encourages researchers to investigate common pathways such as mitochondrial dysfunction and central sensitization.
This study demonstrates association, not causation—migraine does not necessarily cause CFS, and both conditions may stem from a shared underlying vulnerability. The study relies on administrative health records with diagnostic codes, which may not capture clinically diagnosed but undocumented cases or reflect true disease prevalence. The findings apply specifically to the Taiwanese population and may not generalize to other ethnic or healthcare system contexts.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Lau, Chi-ieong, Lin, Che-Chen, Chen, Wei-Hung, Wang, Han-Cheng, & Kao, Chia-Hung (2015). Increased risk of chronic fatigue syndrome in patients with migraine: A retrospective cohort study.. Journal of psychosomatic research. https://doi.org/10.1016/j.jpsychores.2015.10.005
BibTeX
@article{mecfsatlas-lau-2015-increased-risk,
author = {Lau, Chi-ieong and Lin, Che-Chen and Chen, Wei-Hung and Wang, Han-Cheng and Kao, Chia-Hung},
title = {Increased risk of chronic fatigue syndrome in patients with migraine: A retrospective cohort study.},
journal = {Journal of psychosomatic research},
year = {2015},
doi = {10.1016/j.jpsychores.2015.10.005},
note = {PubMed: 26505533},
url = {https://www.mecfsatlas.com/evidence/lau-2015-increased-risk},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/lau-2015-increased-risk
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