Lavergne, M Ruth, Cole, Donald C, Kerr, Kathleen et al. · Canadian family physician Medecin de famille canadien · 2010
This study looked at 128 patients with ME/CFS, fibromyalgia, or multiple chemical sensitivity seen at a Toronto clinic to understand how much these illnesses affect daily life. Compared to healthy Canadians, these patients had significantly lower ability to work, care for themselves, and function in their homes—with 69% having stopped working an average of 3 years after becoming ill. The study found that having fibromyalgia, becoming ill at a younger age, and lower income were linked to worse functional outcomes.
This study provides quantitative evidence of the substantial functional disability experienced by ME/CFS patients during their working years, demonstrating that these illnesses are not minor conditions. The findings highlight the urgent need for early diagnosis, comprehensive medical management, and social support systems to prevent deterioration and support patients during their peak productive years.
This study does not establish causation or why these conditions cause functional impairment—only that they are associated with it. The cross-sectional design captures a snapshot in time and cannot determine whether early intervention actually prevents functional decline. It also does not compare treatment outcomes or identify which specific interventions are most effective.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Lavergne, M Ruth, Cole, Donald C, Kerr, Kathleen, & Marshall, Lynn M (2010). Functional impairment in chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivity.. Canadian family physician Medecin de famille canadien. https://pubmed.ncbi.nlm.nih.gov/20154232/
BibTeX
@article{mecfsatlas-lavergne-2010-functional-impairment,
author = {Lavergne, M Ruth and Cole, Donald C and Kerr, Kathleen and Marshall, Lynn M},
title = {Functional impairment in chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivity.},
journal = {Canadian family physician Medecin de famille canadien},
year = {2010},
note = {PubMed: 20154232},
url = {https://www.mecfsatlas.com/evidence/lavergne-2010-functional-impairment},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/lavergne-2010-functional-impairment
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