Li, Zhong-Xian, Zhang, Yu, Yan, Lu-da et al. · Zhongguo zhen jiu = Chinese acupuncture & moxibustion · 2022 · DOI
This study tested whether electroacupuncture (a traditional treatment combining acupuncture with mild electrical stimulation) applied to specific points on the back could reduce fatigue and improve quality of life in people with ME/CFS. Seventy-two patients were randomly assigned to receive either real electroacupuncture or fake electroacupuncture (needles placed at inactive sites with no electrical current). After 6 weeks of treatment, the real electroacupuncture group showed greater improvements in fatigue symptoms and quality of life compared to the sham group.
ME/CFS lacks effective disease-modifying treatments, making evaluation of potential interventions important. This study provides mechanistic evidence linking a traditional intervention to alterations in cortical excitability, a potential neurobiological pathway in CFS. Understanding how treatments affect brain function could guide development of new therapeutic approaches for this debilitating condition.
This study does not establish that electroacupuncture is a cure or long-term solution for CFS, as it lacks follow-up beyond the treatment period. The observed changes in motor cortical excitability, while statistically significant, do not prove this is the true mechanism of symptom improvement—changes could be secondary effects or artifacts of measurement. The study is also limited to a Chinese population and cannot be generalized to all CFS patients without replication in diverse populations.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Li, Zhong-Xian, Zhang, Yu, Yan, Lu-da, Lai, Mei-Qi, Xu, Hai-Yan, Wu, Ting, et al. (2022). [Effect of electroacupuncture at back-<i>shu</i> points of five <i>zang</i> on fatigue status and cortical excitability in chronic fatigue syndrome].. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. https://doi.org/10.13703/j.0255-2930.20220124-k0006
BibTeX
@article{mecfsatlas-li-2022-effect-electroacupuncture,
author = {Li, Zhong-Xian and Zhang, Yu and Yan, Lu-da and Lai, Mei-Qi and Xu, Hai-Yan and Wu, Ting and Chen, Rui-Ming and Shi, Guo-Ao and Zhou, Peng},
title = {[Effect of electroacupuncture at back-<i>shu</i> points of five <i>zang</i> on fatigue status and cortical excitability in chronic fatigue syndrome].},
journal = {Zhongguo zhen jiu = Chinese acupuncture & moxibustion},
year = {2022},
doi = {10.13703/j.0255-2930.20220124-k0006},
note = {PubMed: 36397215},
url = {https://www.mecfsatlas.com/evidence/li-2022-effect-electroacupuncture},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-27. https://www.mecfsatlas.com/evidence/li-2022-effect-electroacupuncture
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