Lin, Yu-Fang, Jin, Xiao-Qing, Zhu, Jian-Fang et al. · Zhongguo zhen jiu = Chinese acupuncture & moxibustion · 2021 · DOI
This study tested whether ginger-separated moxibustion (a traditional Chinese medicine technique involving heat applied to the skin over specific points) could help reduce fatigue in ME/CFS patients. Over 4 weeks, patients receiving moxibustion treatment along with normal diet and exercise showed significantly greater improvements in fatigue symptoms compared to those receiving diet and exercise alone. The treatment also appeared to change the types of bacteria in patients' guts in ways that might support better intestinal health.
Intestinal dysbiosis has been proposed as a potential factor in ME/CFS pathophysiology. This study offers preliminary evidence that a non-pharmacological intervention may simultaneously improve fatigue symptoms and favorably modulate gut microbial composition, suggesting a possible mechanistic link between treatment effects and microbiome changes.
This study does not prove that the microbiome changes *caused* the fatigue improvement—the changes are correlational. It also cannot determine whether effects are due to moxibustion itself or placebo/expectancy effects, nor whether benefits persist beyond 4 weeks. The small sample size and single-center design limit generalizability to broader ME/CFS populations.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Lin, Yu-Fang, Jin, Xiao-Qing, Zhu, Jian-Fang, Chen, Yi-Dan, Sheng, Ji-Li, He, Jiao-Jun, et al. (2021). [Ginger-separated moxibustion for chronic fatigue syndrome and its effect on intestinal flora].. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. https://doi.org/10.13703/j.0255-2930.20200210-k0001
BibTeX
@article{mecfsatlas-lin-2021-ginger-separated,
author = {Lin, Yu-Fang and Jin, Xiao-Qing and Zhu, Jian-Fang and Chen, Yi-Dan and Sheng, Ji-Li and He, Jiao-Jun and Jin, Yuan-Yuan},
title = {[Ginger-separated moxibustion for chronic fatigue syndrome and its effect on intestinal flora].},
journal = {Zhongguo zhen jiu = Chinese acupuncture & moxibustion},
year = {2021},
doi = {10.13703/j.0255-2930.20200210-k0001},
note = {PubMed: 33798308},
url = {https://www.mecfsatlas.com/evidence/lin-2021-ginger-separated},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-27. https://www.mecfsatlas.com/evidence/lin-2021-ginger-separated
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