Liu, Zhandong, Wang, Dexin, Xue, Qiming et al. · Nutritional neuroscience · 2003 · DOI
This study looked at the levels of different types of fatty acids in the red blood cells of people with ME/CFS compared to healthy controls. Researchers found that people with ME/CFS had lower levels of two important fatty acids (arachidonic acid and docosahexanoic acid) but higher levels of two others (palmitic acid and oleic acid). The researchers suggested this imbalance might be caused by oxidative stress damaging these fatty acids in the body.
This research suggests that cellular-level fatty acid abnormalities may be present in ME/CFS, potentially indicating underlying metabolic dysfunction. Understanding these biochemical differences could eventually lead to new diagnostic markers or therapeutic interventions targeting fatty acid metabolism in ME/CFS.
This study does not establish whether the fatty acid abnormalities cause ME/CFS symptoms or are merely a consequence of the disease. The cross-sectional design cannot prove causation or determine whether correcting these fatty acid levels would improve patient outcomes. The study also does not definitively identify oxidative stress as the mechanism—it is speculation based on the pattern of results.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Liu, Zhandong, Wang, Dexin, Xue, Qiming, Chen, Jun, Li, Yongjie, Bai, Xiaoli, et al. (2003). Determination of fatty acid levels in erythrocyte membranes of patients with chronic fatigue syndrome.. Nutritional neuroscience. https://doi.org/10.1080/10284150310001640356
BibTeX
@article{mecfsatlas-liu-2003-determination-fatty,
author = {Liu, Zhandong and Wang, Dexin and Xue, Qiming and Chen, Jun and Li, Yongjie and Bai, Xiaoli and Chang, Liwen},
title = {Determination of fatty acid levels in erythrocyte membranes of patients with chronic fatigue syndrome.},
journal = {Nutritional neuroscience},
year = {2003},
doi = {10.1080/10284150310001640356},
note = {PubMed: 14744043},
url = {https://www.mecfsatlas.com/evidence/liu-2003-determination-fatty},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-27. https://www.mecfsatlas.com/evidence/liu-2003-determination-fatty
Contribute
Private, reviewed by a human. Not a public comment thread.