Lowry, Timothy J, Pakenham, Kenneth I · Psychology, health & medicine · 2008 · DOI
This study looked at how ME/CFS affects quality of life in 139 Australian patients. Compared to healthy people, ME/CFS patients had significantly worse physical functioning and 63% experienced serious emotional distress. The severity of physical and mental fatigue, along with how often symptoms occurred, were the strongest predictors of poor physical quality of life.
This study provides evidence that ME/CFS has profound negative effects on both physical and psychological quality of life, with specific factors that predict worse outcomes. Identifying these predictors helps clinicians understand which patients may be at highest risk for severe functional decline and psychological distress, potentially guiding targeted interventions.
This cross-sectional study cannot establish causation—it only shows associations between fatigue severity, symptoms, and quality of life outcomes. It does not determine whether severe fatigue causes poor quality of life, whether poor quality of life worsens fatigue perception, or whether both stem from a common underlying mechanism. The findings are specific to the Australian population studied and may not generalize to other populations.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Lowry, Timothy J & Pakenham, Kenneth I (2008). Health-related quality of life in chronic fatigue syndrome: predictors of physical functioning and psychological distress.. Psychology, health & medicine. https://doi.org/10.1080/13548500701335698
BibTeX
@article{mecfsatlas-lowry-2008-health-related,
author = {Lowry, Timothy J and Pakenham, Kenneth I},
title = {Health-related quality of life in chronic fatigue syndrome: predictors of physical functioning and psychological distress.},
journal = {Psychology, health & medicine},
year = {2008},
doi = {10.1080/13548500701335698},
note = {PubMed: 18350466},
url = {https://www.mecfsatlas.com/evidence/lowry-2008-health-related},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/lowry-2008-health-related
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