Martínez-Martínez, Laura-Aline, Mora, Tania, Vargas, Angélica et al. · Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2014 · DOI
This review examined whether ME/CFS, fibromyalgia, IBS, and interstitial cystitis share a common problem: an overactive stress-response system in the nervous system. Researchers looked at 196 published studies that compared patients with these conditions to healthy controls. They found that about 65% of studies showed these patients have a nervous system stuck in 'overdrive,' which could explain why these conditions often occur together.
This systematic review provides evidence that ME/CFS shares a common autonomic nervous system dysfunction with other medically-recognized conditions, supporting the biological basis of the disease. Understanding that sympathetic overdrive is widespread across these syndromes may guide the development of targeted treatments aimed at restoring nervous system balance rather than simply managing individual symptoms.
This review does not establish that sympathetic dysfunction *causes* these conditions—only that it is frequently observed in them (correlation, not causation). It also does not identify which specific sympathetic abnormalities are primary versus secondary, nor does it determine whether correcting sympathetic dysfunction would improve clinical outcomes. The heterogeneity of measurement methods across studies limits the ability to draw firm quantitative conclusions.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Martínez-Martínez, Laura-Aline, Mora, Tania, Vargas, Angélica, Fuentes-Iniestra, Mario, & Martínez-Lavín, Manuel (2014). Sympathetic nervous system dysfunction in fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and interstitial cystitis: a review of case-control studies.. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. https://doi.org/10.1097/RHU.0000000000000089
BibTeX
@article{mecfsatlas-martnez-martnez-2014-sympathetic-nervous,
author = {Martínez-Martínez, Laura-Aline and Mora, Tania and Vargas, Angélica and Fuentes-Iniestra, Mario and Martínez-Lavín, Manuel},
title = {Sympathetic nervous system dysfunction in fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and interstitial cystitis: a review of case-control studies.},
journal = {Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases},
year = {2014},
doi = {10.1097/RHU.0000000000000089},
note = {PubMed: 24662556},
url = {https://www.mecfsatlas.com/evidence/martnez-martnez-2014-sympathetic-nervous},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/martnez-martnez-2014-sympathetic-nervous
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