Nisenbaum, R, Jones, A, Jones, J et al. · Annals of epidemiology · 2000 · DOI
This study followed 74 ME/CFS patients over two years to track how their symptoms changed over time. Researchers found that symptoms fluctuated throughout the illness, but most symptoms stayed about the same whether someone had been sick for 1 year or 20 years. The only exception was stomach pain, which became more common as illness duration increased.
This study provides longitudinal evidence about symptom patterns in ME/CFS over years of illness, helping patients and clinicians understand that core CFS symptoms tend to persist rather than progressively worsen. Understanding which symptoms remain stable versus change over time informs realistic expectations about disease trajectory and may guide clinical monitoring strategies.
This study does not prove that ME/CFS symptoms never change or worsen—it only examines the likelihood of reporting symptoms 'most of the time' and does not assess symptom severity, functional impact, or patterns of fluctuation/relapse. The small sample size (74 patients) and single geographic location limit generalizability to broader ME/CFS populations. The study cannot explain why stomach pain increases with duration or establish causation for any symptom patterns.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Nisenbaum, R, Jones, A, Jones, J, & Reeves, W (2000). Longitudinal analysis of symptoms reported by patients with chronic fatigue syndrome.. Annals of epidemiology. https://doi.org/10.1016/s1047-2797(00)00119-8
BibTeX
@article{mecfsatlas-nisenbaum-2000-longitudinal-analysis,
author = {Nisenbaum, R and Jones, A and Jones, J and Reeves, W},
title = {Longitudinal analysis of symptoms reported by patients with chronic fatigue syndrome.},
journal = {Annals of epidemiology},
year = {2000},
doi = {10.1016/s1047-2797(00)00119-8},
note = {PubMed: 11018368},
url = {https://www.mecfsatlas.com/evidence/nisenbaum-2000-longitudinal-analysis},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/nisenbaum-2000-longitudinal-analysis
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