Niu, Haijing, Ming, Dong, Papadelis, Christos et al. · Frontiers in neuroscience · 2022 · DOI
This editorial discusses how fatigue affects the brain and brain function. It serves as an introduction to recent research exploring the connections between fatigue and brain activity, highlighting why scientists are interested in understanding how exhaustion impacts our ability to think and function.
This editorial is valuable for ME/CFS patients and researchers because it provides expert perspective on why brain-based research matters for understanding fatigue disorders. By highlighting key neuroscience questions and gaps in current knowledge, it helps explain the scientific rationale behind investigating neurological mechanisms in conditions like ME/CFS.
As an editorial, this work does not present original experimental data, clinical findings, or mechanistic proof. It does not establish causal relationships between brain changes and fatigue, nor does it provide evidence specific to any particular fatigue condition or treatment. Editorials are interpretive reviews rather than evidence-generating studies.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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