Novak, Peter, Systrom, David M, Marciano, Sadie P et al. · Scientific reports · 2024 · DOI
This study examined whether questionnaires that ask patients about autonomic symptoms (like dizziness, heart racing, or sweating problems) match what doctors find when they perform actual autonomic tests. Researchers studied over 2,600 patients and found a surprising disconnect: questionnaires and actual tests did not correlate with each other, meaning some patients reported severe symptoms but tested normally, while others had significant test abnormalities but reported few symptoms. This finding held true across many conditions, including ME/CFS, suggesting that questionnaires alone cannot reliably detect autonomic problems.
For ME/CFS patients, this finding is crucial because many rely on symptom questionnaires for initial screening and diagnosis. The study reveals that self-reported autonomic symptoms may not accurately reflect underlying autonomic dysfunction, meaning some ME/CFS patients with real autonomic problems might be missed or dismissed if only questionnaires are used. This research supports the need for objective testing protocols in ME/CFS evaluation and highlights why relying solely on symptom reports is insufficient for diagnosis and treatment planning.
This study does not prove that autonomic dysfunction is absent in ME/CFS, only that questionnaires are poor predictors of objective test results. It does not explain why this mismatch occurs—whether certain patients have atypical autonomic presentations, psychiatric overlay, or different pathophysiological mechanisms. The cross-sectional design cannot establish causation or determine whether the subjective-objective gap widens or narrows over time with disease progression or treatment.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Novak, Peter, Systrom, David M, Marciano, Sadie P, Knief, Alexandra, Felsenstein, Donna, Giannetti, Matthew P, et al. (2024). Mismatch between subjective and objective dysautonomia.. Scientific reports. https://doi.org/10.1038/s41598-024-52368-x
BibTeX
@article{mecfsatlas-novak-2024-mismatch-between,
author = {Novak, Peter and Systrom, David M and Marciano, Sadie P and Knief, Alexandra and Felsenstein, Donna and Giannetti, Matthew P and Hamilton, Matthew J and Nicoloro-SantaBarbara, Jennifer and Saco, Tara V and Castells, Mariana and Farhad, Khosro and Pilgrim, David M and Mullally, William J},
title = {Mismatch between subjective and objective dysautonomia.},
journal = {Scientific reports},
year = {2024},
doi = {10.1038/s41598-024-52368-x},
note = {PubMed: 38291116},
url = {https://www.mecfsatlas.com/evidence/novak-2024-mismatch-between},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-25. https://www.mecfsatlas.com/evidence/novak-2024-mismatch-between
Contribute
Private, reviewed by a human. Not a public comment thread.