O'Dowd, Hazel, Beasant, Lucy, Ingram, Jenny et al. · Pilot and feasibility studies · 2020 · DOI
Researchers wanted to test whether early treatment could prevent long-term fatigue (ME/CFS) from developing in people who had recently become ill. They offered some patients psychological support and cognitive behavioural therapy alongside their regular care. However, the study found that doctors struggled to identify patients early enough, and some patients didn't find the treatment approach helpful for their situation.
This study provides important information about how to design future early intervention trials for ME/CFS, identifying practical barriers that researchers and clinicians need to address. Understanding why patients and healthcare providers found certain approaches challenging can help shape more acceptable and feasible interventions. The findings highlight that preventing ME/CFS progression may require different approaches than those tested here.
This study does not demonstrate whether early intervention can or cannot prevent ME/CFS from developing, as the feasibility barriers prevented adequate testing of the intervention's effectiveness. The study's inability to recruit at predicted rates does not prove early intervention is ineffective—only that this particular recruitment method and intervention format were problematic. No conclusions can be drawn about outcomes or efficacy due to the trial's feasibility design rather than its power for statistical analysis.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
O'Dowd, Hazel, Beasant, Lucy, Ingram, Jenny, Montgomery, Alan, Hollingworth, Will, Gaunt, Daisy, et al. (2020). The feasibility and acceptability of an early intervention in primary care to prevent chronic fatigue syndrome (CFS) in adults: randomised controlled trial.. Pilot and feasibility studies. https://doi.org/10.1186/s40814-020-00595-0
BibTeX
@article{mecfsatlas-odowd-2020-feasibility-acceptability,
author = {O'Dowd, Hazel and Beasant, Lucy and Ingram, Jenny and Montgomery, Alan and Hollingworth, Will and Gaunt, Daisy and Collin, Simon M and Horne, Sarah and Jones, Beth and Crawley, Esther},
title = {The feasibility and acceptability of an early intervention in primary care to prevent chronic fatigue syndrome (CFS) in adults: randomised controlled trial.},
journal = {Pilot and feasibility studies},
year = {2020},
doi = {10.1186/s40814-020-00595-0},
note = {PubMed: 32426159},
url = {https://www.mecfsatlas.com/evidence/odowd-2020-feasibility-acceptability},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/odowd-2020-feasibility-acceptability
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