Pedersen, B K, Saltin, B · Scandinavian journal of medicine & science in sports · 2006 · DOI
This review examined whether exercise therapy helps treat many different diseases, including chronic fatigue syndrome (ME/CFS). The authors looked at evidence showing how exercise affects disease causes, symptoms, fitness, and quality of life across multiple conditions. They also discussed how much exercise is safe and effective for each disease.
For ME/CFS patients and researchers, this review is important because it positions ME/CFS alongside other chronic diseases in the exercise therapy literature and provides a framework for evaluating exercise's role in disease management. However, this broad-spectrum approach may not adequately address ME/CFS-specific challenges, particularly post-exertional malaise (PEM), which distinguishes ME/CFS from most other chronic diseases reviewed.
This review does not prove that standard exercise prescriptions used for other chronic diseases are appropriate for ME/CFS. It does not differentiate between diseases where exercise is universally beneficial and those (like ME/CFS) where exercise may be harmful for some patients. The inclusion of ME/CFS alongside conditions with different pathophysiology does not establish that mechanisms of exercise benefit are comparable.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Pedersen, B K & Saltin, B (2006). Evidence for prescribing exercise as therapy in chronic disease.. Scandinavian journal of medicine & science in sports. https://doi.org/10.1111/j.1600-0838.2006.00520.x
BibTeX
@article{mecfsatlas-pedersen-2006-evidence-prescribing,
author = {Pedersen, B K and Saltin, B},
title = {Evidence for prescribing exercise as therapy in chronic disease.},
journal = {Scandinavian journal of medicine & science in sports},
year = {2006},
doi = {10.1111/j.1600-0838.2006.00520.x},
note = {PubMed: 16451303},
url = {https://www.mecfsatlas.com/evidence/pedersen-2006-evidence-prescribing},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/pedersen-2006-evidence-prescribing
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