Pietrangelo, T, Mancinelli, R, Toniolo, L et al. · International journal of immunopathology and pharmacology · 2009 · DOI
Researchers examined muscle tissue from ME/CFS patients and found abnormalities in how genes are expressed—essentially, certain genetic instructions were turned up or down compared to healthy people. The biggest changes involved genes related to energy production in cells, muscle structure, and communication between nerves and muscles. These findings suggest that problems at the cellular level may explain why ME/CFS patients experience muscle weakness and fatigue.
This study provides molecular-level evidence that ME/CFS muscle symptoms have a biological basis rather than being purely psychological, which validates patient experiences and may guide future therapeutic targets. Identifying specific genes and pathways involved in muscle dysfunction could lead to biomarkers for diagnosis and inform treatment strategies.
This study demonstrates correlational findings in muscle tissue but does not prove these gene expression changes directly cause muscle symptoms or ME/CFS. The research does not establish whether these changes occur in all ME/CFS patients, progress over time, or respond to treatment. Additionally, altered gene expression may be a consequence of the disease rather than an initiating factor.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Pietrangelo, T, Mancinelli, R, Toniolo, L, Montanari, G, Vecchiet, J, Fanò, G, et al. (2009). Transcription profile analysis of vastus lateralis muscle from patients with chronic fatigue syndrome.. International journal of immunopathology and pharmacology. https://doi.org/10.1177/039463200902200326
BibTeX
@article{mecfsatlas-pietrangelo-2009-transcription-profile,
author = {Pietrangelo, T and Mancinelli, R and Toniolo, L and Montanari, G and Vecchiet, J and Fanò, G and Fulle, S},
title = {Transcription profile analysis of vastus lateralis muscle from patients with chronic fatigue syndrome.},
journal = {International journal of immunopathology and pharmacology},
year = {2009},
doi = {10.1177/039463200902200326},
note = {PubMed: 19822097},
url = {https://www.mecfsatlas.com/evidence/pietrangelo-2009-transcription-profile},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/pietrangelo-2009-transcription-profile
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