Polich, J, Moore, A P, Wiederhold, M D · Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 1995 · DOI
This study measured electrical activity in the brains of people with ME/CFS and healthy controls using a simple listening task where they had to identify specific sounds. Researchers found no differences in brain wave patterns (called P300) between the two groups, even though many ME/CFS patients report problems with memory and attention. This suggests that brain electrical activity measured this way may not be a reliable marker for ME/CFS.
Brain biomarkers could potentially help validate ME/CFS as a physiological condition and support patients in diagnosis and treatment planning. Understanding why cognitive symptoms persist despite normal brain electrical responses to attention-demanding tasks provides important insights into ME/CFS pathophysiology and helps researchers identify which brain measures may or may not be useful for diagnosis.
This study does not prove that ME/CFS patients do not have real cognitive deficits—only that this particular brain measurement does not detect them. The absence of P300 differences does not rule out abnormalities in other brain systems, brain regions, or different types of cognitive testing. A negative finding in one biomarker does not indicate cognitive complaints are non-neurological.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Polich, J, Moore, A P, & Wiederhold, M D (1995). P300 assessment of chronic fatigue syndrome.. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. https://doi.org/10.1097/00004691-199503000-00009
BibTeX
@article{mecfsatlas-polich-1995-p300-assessment,
author = {Polich, J and Moore, A P and Wiederhold, M D},
title = {P300 assessment of chronic fatigue syndrome.},
journal = {Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society},
year = {1995},
doi = {10.1097/00004691-199503000-00009},
note = {PubMed: 7797633},
url = {https://www.mecfsatlas.com/evidence/polich-1995-p300-assessment},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/polich-1995-p300-assessment
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