Portwood, M F · The Nurse practitioner · 1988
This article helps doctors recognize ME/CFS by describing its many symptoms, which can range from mild tiredness to severe disability. Patients often report feeling exhausted, achy, and unable to concentrate, yet standard medical tests often appear normal. The article emphasizes that doctors should take these symptoms seriously and help patients manage their condition, even though there is currently no cure.
This article was important in 1988 for raising clinical awareness of ME/CFS among healthcare providers who might otherwise dismiss or misdiagnose patients. It emphasizes the legitimacy of the illness and the healthcare provider's role in recognizing this confusing disorder, which was particularly valuable during a period when ME/CFS lacked widespread clinical recognition.
This review does not establish the cause of ME/CFS, provide treatment efficacy data, or offer diagnostic criteria validated through systematic research. It does not prove why symptoms appear disproportionate to physical findings, nor does it define which symptomatic treatments are most effective. As a clinical opinion piece rather than an empirical study, it cannot establish causation or quantify disease burden.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Portwood, M F (1988). Chronic fatigue syndrome--a diagnosis for consideration.. The Nurse practitioner. https://pubmed.ncbi.nlm.nih.gov/2830563/
BibTeX
@article{mecfsatlas-portwood-1988-chronic-fatigue,
author = {Portwood, M F},
title = {Chronic fatigue syndrome--a diagnosis for consideration.},
journal = {The Nurse practitioner},
year = {1988},
note = {PubMed: 2830563},
url = {https://www.mecfsatlas.com/evidence/portwood-1988-chronic-fatigue},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/portwood-1988-chronic-fatigue
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