Prajjwal, Priyadarshi, Kalluru, Pavan K R, Marsool, Mohammed Dheyaa et al. · Annals of medicine and surgery (2012) · 2023 · DOI
This review examines how multiple sclerosis (MS) and ME/CFS are similar, particularly in how they cause fatigue and affect sleep. Both conditions involve damage to similar brain regions and may share genetic risk factors. The authors discuss how treatments like supervised exercise can help manage fatigue in both illnesses, though the underlying causes differ.
Understanding the biological similarities between MS and ME/CFS could improve diagnosis and treatment of ME/CFS, a condition often poorly understood and undertreated. Identifying shared genetic and neuroimaging markers may accelerate research into ME/CFS mechanisms. The discussion of effective fatigue management strategies provides evidence-based options for patients managing persistent fatigue.
This narrative review does not establish causal mechanisms or definitive diagnostic criteria distinguishing MS from ME/CFS. It does not prove that genetic overlaps indicate identical disease pathophysiology, nor does it establish that exercise interventions work equally well across both conditions. The correlation of neuroimaging findings does not confirm they cause fatigue in the same way in both diseases.
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The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Prajjwal, Priyadarshi, Kalluru, Pavan K R, Marsool, Mohammed Dheyaa, Inban, Pugazhendi, Gadam, Srikanth, Al-Ezzi, Saud M S, et al. (2023). Association of multiple sclerosis with chronic fatigue syndrome, restless legs syndrome, and various sleep disorders, along with the recent updates.. Annals of medicine and surgery (2012). https://doi.org/10.1097/MS9.0000000000000929
BibTeX
@article{mecfsatlas-prajjwal-2023-association-multiple,
author = {Prajjwal, Priyadarshi and Kalluru, Pavan K R and Marsool, Mohammed Dheyaa and Inban, Pugazhendi and Gadam, Srikanth and Al-Ezzi, Saud M S and Marsool, Ali Dheyaa and Al-Ibraheem, Abdullah M T and Al-Tuaama, Abdullah Z H and Amir, Omniat and Arunachalam, Shivaram P},
title = {Association of multiple sclerosis with chronic fatigue syndrome, restless legs syndrome, and various sleep disorders, along with the recent updates.},
journal = {Annals of medicine and surgery (2012)},
year = {2023},
doi = {10.1097/MS9.0000000000000929},
note = {PubMed: 37363482},
url = {https://www.mecfsatlas.com/evidence/prajjwal-2023-association-multiple},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/prajjwal-2023-association-multiple
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