Puri, Basant K · International review of psychiatry (Abingdon, England) · 2006 · DOI
Researchers developed advanced brain imaging techniques to detect small structural changes in the brain over time by comparing multiple MRI scans with extremely high precision. They used these techniques to study whether a type of fish oil supplement (EPA) might affect brain structure in people with various conditions, including ME/CFS. This study focuses on the imaging methods themselves rather than reporting final results about whether the treatment worked.
For ME/CFS researchers, this study provides validated neuroimaging methodology that could detect subtle brain structural changes associated with the disease or its treatment response. Since ME/CFS involves potential neurobiological changes that may not be visible with standard imaging, these high-precision techniques could reveal previously undetectable abnormalities that help understand disease mechanisms.
This is a methods paper, not a clinical trial, so it does not prove that EPA or any other treatment is effective for ME/CFS or the other conditions studied. It does not demonstrate whether any actual brain changes occurred in patients, only that the imaging techniques are capable of detecting such changes if they exist. The study design does not establish causation between any intervention and structural brain outcomes.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Puri, Basant K (2006). High-resolution magnetic resonance imaging sinc-interpolation-based subvoxel registration and semi-automated quantitative lateral ventricular morphology employing threshold computation and binary image creation in the study of fatty acid interventions in schizophrenia, depression, chronic fatigue syndrome and Huntington's disease.. International review of psychiatry (Abingdon, England). https://doi.org/10.1080/09540260600583015
BibTeX
@article{mecfsatlas-puri-2006-high-resolution,
author = {Puri, Basant K},
title = {High-resolution magnetic resonance imaging sinc-interpolation-based subvoxel registration and semi-automated quantitative lateral ventricular morphology employing threshold computation and binary image creation in the study of fatty acid interventions in schizophrenia, depression, chronic fatigue syndrome and Huntington's disease.},
journal = {International review of psychiatry (Abingdon, England)},
year = {2006},
doi = {10.1080/09540260600583015},
note = {PubMed: 16777669},
url = {https://www.mecfsatlas.com/evidence/puri-2006-high-resolution},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/puri-2006-high-resolution
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